FORMULATION AND EVALUATION OF ENTERIC COATING TABLETS BY WET GRANULATION METHOD
Journal Title: Int J of Preclin & Pharm Res - Year 2014, Vol 4, Issue 3
Abstract
ABSTRACT Serratiopeptidase is derived from bacteria belonging to genus Serratia. Serratiopeptidase tablets used in the treatment of viral diseases and hepatitis. Serratiopeptidase were formulated using HPMC phthalate as enteric coating polymer in different concentrations to optimize delayed drug release profile and to target the drug release in the small intestine regions. The present work was made to develop enteric coated tablets containing Serratiopeptidase tablets were made by direct compression method. The tablets were evaluated for physical characterization, in vitro release study and stability studies. Results of in vitro release profile indicated that formulation F1 was the most promising formulation as the extent of drug release from this formulation was optimum and match with the In-house Specification when compared to other formulations. Keywords: Enteric coated tablets, Serratiopeptidase, Hydroxylpropylmethylcellulose, In-vitro release studies.
Authors and Affiliations
B. Shibu*, S. Suresh, M. Purushothaman, C. Saravanan, C. J. Lissy Joice
Keywords
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