A REVIEW ON COMBINATORIAL CHEMISTRY IN DRUG DISCOVERY
Journal Title: Int J of Preclin & Pharm Res - Year 2012, Vol 2, Issue 2
Abstract
ABSTRACT Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but often structurally related molecules or materials. In a combinatorial synthesis, the number of compounds made increases exponentially with the number of chemical steps. In a binary light-directed synthesis, 2n compounds can be made in n chemical steps. Combinatorial chemistry is especially common in CADD (Computer aided drug design) and can be done online with web based software, such as Molinspiration. The present review focused on synthesis of molecules in a combinatorial fashion can quickly lead to large numbers of molecules. Keywords: Combinatorial chemistry, Lead molecule, Applications.
Authors and Affiliations
A. Elumalai* and M. Chinna Eswariah
Keywords
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