STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF TELBUVIDINE BY RPHPLC IN BULK DRUG
Journal Title: Asian J of Pharm Sci & Tech - Year 2015, Vol 5, Issue 2
Abstract
ABSTRACT A new simple and precise reverse phase high performance liquid chromatographic method has been developed and subsequently validated for the estimation of Telbuvidine in bulk form. The chromatographic separation was performed by using mobile phase consisting of acetonitrile and buffer in the ratio of 70:30 % v/v. The column used was ODS-HG-5 (150×4.6 mm, 5μ) with flow rate of 0.8 ml/min using PDA detection at274nm. The described method was found to be linear over the range of 70-120μg/ml and correlation coefficient was found to be 0.993. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise, reliable, accurate and economical which is useful for the routine determination of Telbuvidine (API) in bulk dosage form. Key words: Telbuvidine, Reverse phase high performance liquid chromatography.
Authors and Affiliations
Sangeetha D*, Shyamala, Sharma JVC, Swarupa A
Keywords
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