EFFECT OF TOXOPLASMOSIS AND ITS TREATMENTS ON MALE RAT REPRODUCTIVE FUNCTIONS
Journal Title: Asian J of Pharm Sci & Tech - Year 2016, Vol 6, Issue 2
Abstract
ABSTRACT In comparison with the non infected male rats, toxoplasmosis significantly decreased serum FSH 79.7±8.2 ng/ml (P<0.01), LH 3.62±0.6 ng/ml (P<0.05), testosterone 0.96±0.1 ng/ml (P<0.01), sperm count / mg of epididymal cauda 253 ±12 X106 (P<0.01), sperm viability percent 28.8 ±1.8% (P<0.01), the relative weight of the testis and seminal vesicle (P<0.001), prostate (P<0.01) and epididymis (P<0.05), pregnancy rate 86%(P<0.01), litter size 6.29±0.92 (P<0.001), fetal weight 0.367±0.038g (P<0.05) and placental weight 0.282±0.012g (P<0.05); while it significantly increased sperm malformation percent 1.6 ±0.3% (P<0.001), fetal resorption rate 2.222% (P<0.05) and early fetal death percent 8.07% (P<0.01). Sulphadiazine or pyrimethamine can enhance some of the fertility parameter in toxoplasma infected rats, but they were not free from adverse effects which decreased pregnancy rate, litter size, fetal weight and increased fetal resorption and early fetal death. Key words: Fertility, Reproductive functions, Rats, Toxoplasmosis, Sulphadiazine, Pyrimethamine.
Authors and Affiliations
Zahraa Sadoon Al-Ghezy, Fadhil Abbas Al-Abady, Ali Esmail Al-Snafi*
Keywords
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