FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF CIPROFLOXACIN
Journal Title: Asian J of Pharm Sci & Tech - Year 2013, Vol 3, Issue 2
Abstract
ABSTRACT Gastro retentive dosage forms have the potential use as control released systems. For prolonged gastric retention floating drug delivery is of particular interest, for drugs which, act locally in the stomach, primarily absorbed in the stomach or upper intestine, poorly soluble at alkaline pH, have a narrow window of absorption, and are unstable in the intestinal pH. With the sustained release floating matrix tablets of prolonging gastric residence time with controlled release mechanisms achieves improved patient compliance. Gastric retention drug delivery systems can be retained in stomach for a long time, such systems which are retained in stomach are important for drugs which are easily degraded .present work is to formulate sustained release floating matrix tablets of ciprofloxacin using different polymeric concentrations and evaluating all formulations and notifying the optimized formulation. In present investigation the effect of different concentrations of different polymers (HPMC K4M and HPMC K100M) on the drug release from Ciprofloxacin floating matrix tablets were studied. The tablets were subjected to all physical characteristics evaluation, formulation containing F8 and F9 showed desired duration of floating time for 9 hours, and drug release. Key words: Ciprofloxacin, Floating drug delivery system, HPMC, Gastro retentive drug delivery system.
Authors and Affiliations
*Someshwar K, Eswar Kumar A, Vishali D, Samba Murthy U, Varsha Banglae
Keywords
Related Articles
- EP ID EP96276
- DOI -
- Views 268
- Downloads 0
MEDICINAL CHASMOPHYTES OF URUMBIKKARA HILLS, IDUKKI DISTRICT, KERALA, INDIA
ABSTRACT The present paper shows 45 species of medico-potential chasmophytes from Urumbikkara Hills of Idukki district, Kerala. These medicinal plants are used either their any part only or the whole plant for th...
[i][/i] ISOLATION OF EXTRACELLULAR PROTEINS FROM SOIL
ABSTRACT The present research work was to investigate and isolate extracellular proteins three different farm soils. Soil samples were homogenized to remove large roots and stones, stored in dark at 4°C until use...
DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF GRANISETRON HCL WITH NATURAL AND SYNTHETIC POLYMERS
ABSTRACT Granisetron HCl is a novel serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting during cancer chemotherapy but its oral bioavailability is low due to extensive first-pas...
ANTINOCICEPTIVE EFFECTS OF STIGMASTEROL AND 9-HEXACOSENE ISOLATED FROM MONDIA WHYTEI (HOOK.F.) ROOT
ABSTRACT Mondiawhytei is used for treatment of dysmennorrhea, gastro intestinal colic, post partum pains among other uses in the practice of traditional medicine in Africa. In the present study, the in vivoantin...
FIVE-PARAMETER TYPE I GENERALIZED LOGISTIC DISTRIBUTION
ABSTRACT In this paper, we consider further generalization of the four-parameter type I generalized logistic distributions in Olapade (2004) to a five-parameter type I generalized logistic distribution. Some theo...