ANTINOCICEPTIVE EFFECTS OF STIGMASTEROL AND 9-HEXACOSENE ISOLATED FROM MONDIA WHYTEI (HOOK.F.) ROOT
Journal Title: Asian J of Pharm Sci & Tech - Year 2012, Vol 2, Issue 1
Abstract
ABSTRACT Mondiawhytei is used for treatment of dysmennorrhea, gastro intestinal colic, post partum pains among other uses in the practice of traditional medicine in Africa. In the present study, the in vivoantinociceptive effects of two compounds,stigmasterol and 9-hexacosene isolated fromMondiawhytei roots has been investigated. Bioactivity guided extraction and isolation of stigmasterol and 9-hexacosene was carried out.The formalin test was used inassessing the antinociceptive activity. Stigmasterol reduced the time spent licking, biting and/or lifting the injected paw in both the early and late phases of the formalin test. This reduction was found to be dose dependent and statistically significant (p<0.001) at a dose of 30mg/kg body weight. 9-hexacosene produced dose-dependent and statistically significant (p<0.001) antinociceptive effect on the late phase of the formalin test at a dose of 7.5mg/kg body weight. No motor, neurological or other behavioral deficits were observed. Results of the present study supported the utilization of Mondiawhytei in Africa folk medicine and revealed stigmasterol and 9-hexacosene as the major antinociceptive principles in the roots. Key words: Mondiawhytei, Antinociception, Stigmasterol, 9-hexacosene, Formalin test
Authors and Affiliations
Githinji C. G*, P. M. Mbugua, T. I. Kanui and D. K. Kariuki
Keywords
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