DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF GRANISETRON HCL WITH NATURAL AND SYNTHETIC POLYMERS
Journal Title: Asian J of Pharm Sci & Tech - Year 2013, Vol 3, Issue 1
Abstract
ABSTRACT Granisetron HCl is a novel serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting during cancer chemotherapy but its oral bioavailability is low due to extensive first-pass metabolism in liver which makes it an ideal candidate for Fast dissolving drug delivery system. The present study aimed to develop fast disintegrating tablets of Granisetron HCl using natural superdisintegrants like Plantago ovata, Gum Karaya and Agar & synthetic superdisintegrants like Indion 234, Croscaramellose sodium, Sodium starch glycolate and crospovidone. Precompressional studies revealed good micromeritic properties of powder blend. Various Formulations of were prepared by direct compression method and were evaluated for their physico chemical properties, drug release and stability studies. FTIR and DSC show that there is no interaction with drug and other excipients. The hardness, friability, drug content and disintegration time of fast dissolving tablets were found uniform and reproducible. Dissolution test shows that 5 % w/w concentration was found optimum. Selected Formulation F4 were subjected to FTIR and DSC that shows that is compatible and release was found superior to marketed conventional tablets with respect to disintegration and dissolution and found to be stable. Stability studies shows that there is no much more differences in their release. Key words: Fast disintegrating tablets, Granisetron HCl, Superdisintegrants.
Authors and Affiliations
*B. Sunil Kumar Reddy, Shubhrajit Mantry, S. Anil Kumar, E. Satheesh Kumar
Keywords
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