Study of antioxdant, antiinflammatory and woundhealing activity of extracts of Litsea glutinosa
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 3
Abstract
Present work was undergone to investigate antioxidant and anti inflammatory and wound healing effects of Litsea glutinosa in rats. The aqueous extract of Litsea glutinosa (250 and 500 mg/kg body weight) was studied for ant inflammatory in animal models. The activity was studied in some acute models Viz carragenan , histamine and dextrin induced rats paw edema against indomethacin as standard, and it showed significant anti inflammatory activity in all the three models. The preliminary phytochemical analysis was carried out for different extracts. It was found that flavone glycosides, reducing sugars, aminoacids and tannins. The ethanolic extract was screened for wound healing activity by excision and incison wound model, in the form of an ointment having 2 concentrations( 3 and 5 % w/w) of leaf extract in simple ointment base. Both the concentrations of the ethanolic extract showed significant response in both the wound types tested when compared with the control group. Nitrofurazone ointment (0.2%w/w) was used as an standard drug. Antioxidant activity was determined by two in vitro methods- DPPH and H2O2 radical scavenging . The extract having significant (p<0.001 and p<0.0001) antioxidant activity compared to control. BHT and Ascorbic acid were used as reference standard for antioxidant activity. On the basis of the results obtained suggest marked that extracts have significant Anti oxidant , Anti inflammatory and wound healing activity of Litsea glutinosa. The results supported the traditional use of this plant in some painful and inflammatory conditions.
Authors and Affiliations
P. Devi , R. Meera
Keywords
Related Articles
- EP ID EP139622
- DOI -
- Views 123
- Downloads 0
Ethnopharmacological study of plants used to treat malaria, in traditional medicine, by Bete Populations of Issia (Côte d’Ivoire)
Malaria is the major tropical pathology in developing countries and man used the medicinal properties of many plants to fight this disease. During an ethnopharmacological survey in 13 villages of Issia, a Department...
Formulation Development and Evaluation of Ondansetron Hydrochloride sustained release Matrix tablets
The objective of the present study was to develop sustained release matrix tablets of Ondansetron hydrochloride [5mg] formulated employing Hydroxy Propyl Methyl Cellulose polymer and the sustained release ...
VALIDATED RP-HPLC METHOD FOR FLUVASTATIN SODIUM IN BULK AND ITS DOSAGE FORM
A Simple, selective and rapid reverse-phase high Performance Liquid Chromatography (RP-HPLC) method for the analysis of fluvastatin sodium in bulk and in tablet dosage form has been developed and validated. The method wa...
Antioxidant properties and in vitro immunomodulatory effects of peppermint (Mentha x piperita l.) Essential oils in human leukocytes
Peppermint (Mentha x piperita L.) is popular in folk medicine. Its immune effects however received so far limited attention. In the present study, peppermint oils from two cultivars (RAC 541 and Laimburg) grow...
Optimization, Formulation and In-Vitro Evaluation of Mouth Dissolving Tablets of Levocetrizine Hydrochloride for the Treatment of Allergic Rhinitis
New era is an era of novel drug delivery systems. Pediatric, Geriatric and bed ridden patients have difficulties in swallowing tablets. The purpose of the present study was to develop and characterize mouth dissolving ta...