STUDY OF METABOLIC SYNDROME IN DIABETIC AND NON-DIABETICS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 20
Abstract
[b] BACKGROUND:[/b] The metabolic syndrome is a cluster of cardiovascular risk factors like diabetes, hypertensions, abdominal obesity and dyslipidemia. In addition, people with metabolic syndrome have a fivefold greater risk of developing Type-2 diabetes. The current study analyzes the incidence of metabolic syndrome in diabetic and non-diabetic patients and its associates with individual risk factors. [b]AIM: [/b]To estimate the incidence of metabolic syndrome in diabetic and nondiabetic Patients. [b]METHODS: [/b]The data for this study was collected from 50 patients with diabetes mellitus and non-diabetic patients (matched controls) who presented to the Department of medicine, Kempegowda Institute of Medical Science Hospital, Bangalore, during October 2006 to September 2008. A detailed history was taken, clinical examination & anthropometric measurements were undertaken and relevant investigations were asked. Subjects were studied after classifying them in to different groups for comparison of important variables. Data collected for the study was analyzed statistically. [b]RESULTS: [/b]The incidence of Metabolic Syndrome in diabetic subjects (case group) was found to be high i.e., 70%, which statistically significant (6.64 times more & P <0.001) when compared to non-diabetic subjects (Control group), which was only 26%. It has been observed that the incidence of metabolic syndrome increase as the duration of diabetes increases and with worsening glucose tolerance as reflected by high HbA1c levels. Hypertension was found to be more prevalent in diabetic subjects with metabolic syndrome i.e., 70%, whereas in non-diabetic subjects with metabolic syndrome, it was found in only 26%. In the diabetic subjects with metabolic syndrome all 100% had raised triglyceride & LDL levels and 66.7% had low HDL levels. In the non-diabetic subjects with metabolic syndrome triglycerides was raised in 86.7%, whereas raised LDL & low HDL was present in all 100%. The BMI of >25 kg/m2 was found in 70% of diabetic subject with metabolic syndrome whereas in non-diabetic subjects with metabolic syndrome, it was only 27.6%. Raised waist circumference in diabetic subjects with metabolic syndrome was found to be in 70%, whereas non-diabetic subjects with metabolic syndrome the waist circumference was fond to be raised in 86.7%. [b]CONCLUSIONS:[/b] In this study, the incidence of metabolic syndrome in diabetic subject was found to be higher than in non-diabetic. Hypertension was to be more prevalent in diabetic subjects with metabolic syndrome than in non-diabetic subject with metabolic syndrome. Evaluation of BMI & waist circumference for predicting the metabolic syndrome by using the regression analysis revealed that the waist circumference is the better predictor of metabolic syndrome in both diabetic & nondiabetic subjects. Reducing the waist circumference cut off levels as advised by IDF & revised ATP III criteria in high risk population and reducing the BMI as advised by WHO will help to identify more number of people who could then be tested to diagnose metabolic syndrome and ultimately advise intensive life style modification along with therapies for different risk factors to prevent the progression to diabetes and atherosclerotic cardiovascular disease.
Authors and Affiliations
Manjunath R, Deepak Kumar, Vishwanath k
Keywords
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- EP ID EP95613
- DOI 10.14260/jemds/2014/2636
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