Study on phytochemical profile and Anti-ulcerogenic effect of Casuarina equisetifolia (L.)
Journal Title: Asian J of Pharm Sci & Tech - Year 2011, Vol 1, Issue 1
Abstract
ABSTRACT Casuarina equisetifolia (L.) is a member of the Casuarinaceae. It is common along the coast on beaches, rocky coasts, limestone outcroppings, dry hillsides and open forests in both wet and dry zones from sea-level to mid-montane. It is native to South-East Asia, Australia and Polynesia. It is also cultivated as an ornamental, for wind-breaks, or as a medicinal plant in some tropical countries in the South Pacific. To investigate the phytoconstituents, acute oral toxicity and anti-ulcer profile of the Ethanol extract of Casuarina equisetifolia (L.) extract in albino rats. Ethanolic extract at the doses of 200 and 400 mg/kg p.o administered to evaluate anti-ulcer activity by using Ethanol, indomethacin, and cold-restraint stress induced gastric ulcer models in Albino rats. Ethanol extract gave positive results for the alkaloids, reducing sugars, triterpenoids, and flavonoids. Study on acute toxicity of extract was found to be safe at the doses 2000mg/kg p.o. Ethanol extract dose dependent inhibition in ethanol induced gastric lesions, ethanol extract showed 70.37 % protection at 400 mg/kg, and 52.7% protection at 200 mg/kg, In indomethacin induced gastric lesions, Ethanol extract showed 68.3% protection at 400 mg/kg and 51.7% protection at 200 mg/kg, it also dose dependent inhibition in Cold-restraint stress induced gastric lesions, ethanol extract showed 75.02% protection at 400 mg/kg, and 45.86% protection at 200 mg/kg. All the results are found to be statistically significant (p≤0.05). Hence we suggest that ethanol extract possess anti-ulcerogenic properties that may be due to cytoprotective mechanism. These results support the ethnomedical uses of the plant in the treatment of gastric ulcer. Keywords: Casuarina equisetifolia (L.), Antiulcer Activity, Ethanol, Indomethacin, Cold-restraint stress.
Authors and Affiliations
S. Shalini* , A. Saravana Kumar, 1R. Meenakshi Sundaram
Keywords
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