Synthesis of hydrazide-hydrazone derivatives and their evaluation of antidepressant, sedative and analgesic agents
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 4
Abstract
The reaction of cyanoacetylhydrazine (1) with -bromo(4-methoxyacetophenone) (2) gave the hydrazidehydrazone derivative 3. Compound 3 reacted with either potassium cyanide or potassium thiocyanide to give the cyanide or thiocyanide derivatives 4a or 4b respectively. The reaction of compound 3 with either hydrazine hydrate or phenylhydrazine gave the hydrazine derivatives 6a or 6b respectively. The latter compounds underwent a series of heterocyclization when react with different reagents to give 1,3,4-triazine and pyridine derivatives. The antidepressant, sedative and analgesic activities of the newly synthesized products were evaluated.
Authors and Affiliations
R. M. Mohare , K. A. El-Sharkawy , M. M. Hussein , H. M. El-Sehrawi
Keywords
Related Articles
- EP ID EP124136
- DOI -
- Views 119
- Downloads 0
Polysaccharide gum matrix tablets for oral controlled delivery of Cimetidine
Matrix-based tablets using 40 %w/w grewia gum were prepared by direct compression to contain cimetidine as novel drug. The formulations were compared with similar formulations using hydroxypropyl methylce...
Invitro Anti helmentic Activity of aqueous and alcoholic extracts of Aerva lanata Seeds and leaves
The antiparasitic activity of the seed and leaf extracts of Aerva lanata (Amaranthaceae) were tested against a tapeworm and an earthworm, particularly ethanolic extract showing to be better against tapeworms and earthwor...
Design, Synthesis and Antiinflammatory Activity of Novel -Tocopherol Acetylsalicylic acid Ester Codrug
Acetylsalicylic acid (ASA) is the most widely used drug for the prevention of thrombotic risk in the heart, brain and peripheral circulation. Different reports suggest that vitamin E decreases neuronal cell death cause...
Novel Inclusion Complexs Of Oseltamivir Phosphate-With ß Cyclodextrin: Physico-Chemical Characterization.
The purpose of this research was to mask the intensely bitter taste of Oseltamivir Phosphate (OP) Taste masking was done using beta-cyclodextrin (CD). Prepared complexes were characterized using several techniques, nam...
Identification, Prevention and Management of Risks Associated With Hepatic Encephalopathy -A Review
Hepatic encephalopathy (HE) is a neuropsychiatric complication of either acute or chronic hepatic insufficiency. Aim was to analyze the precipitating factors of hepatic encephalopathy and to determine therapeutic approac...