Synthesis, Spectral investigation (1H, 13C) and Anti-microbial Screening of benzophenone imines
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 6
Abstract
New series of benzophenone imines with general formula Ph2-C=NR; R = Benzyl, 4-Fluorobenzyl, Naphthyl, Phenyl, 4-Nitrophenyl were synthesized by condensation of dichlorodiphenylmethane and different aromatic primary amines (1:1) Those imines were characterized by different physiochemical and spectroscopic techniques like melting point, elemental analysis, FT-IR, multinuclear NMR (1H, 13C). After characterization, imines were subjected to anti-microbial activities. All compounds showed promising activity against different bacterial strains like Escherichia coli, Bacillussubtilis, Pasturellam ultocida and Staphylococcus aureus as well as fungal strains like Alternata alternaria, Ganoderma lucidium, Penicillium notatum and Trichoderma harzianum using Amoxicillin and Flucanazole as a standard drugs respectively.
Authors and Affiliations
Muhammad Kaleem Khosa , Muhammad Asghar Jamal , Muhammad Jawad Saif , Majid Muneer , Fazal-ur-Rehman , Muhammad Farman , Hafiz Muhammad Shoaib , Muhammad Shahid , Shabnam Hameed1
Keywords
Related Articles
- EP ID EP101213
- DOI -
- Views 106
- Downloads 0
Comparing the effects of manual therapy versus electrophysical agents in the management of knee osteoarthritis
To evaluate the effectiveness of Manual Therapy in comparison to Electrophysical agents in Knee Osteoarthritis. Total 50 patients with knee osteoarthritis were recruited from OPD of orthopedics civil hospital and I...
The effects of the leaf water extract of Struchium sparganophora (Linn.) Ktze asteraceae on the hematopoietic parameters and the organ system of rats
Struchium sparganophora, (Linn.) Asteraceae is a culinary herb consumed in the western part of Nigeria and it is known to have a nutritive value. This study was carried out to assess its’ effects on the hematopoiet...
Gas chromatography coupled with mass spectrometric characterization of Curcuma longa: Protection against pathogenic microbes and lipid peroxidation in rat’s tissue homogenate
The present study was designed to investigate the mineral content and antimicrobial activity of Curcuma Longa extracts and its essential oil. We also determined the lipid peroxidation inhibition activity of the eth...
Anti-HIV-1 activities of extracts and phenolics from Smilax china L.
Four extracts (EtOH, CHCl3, EtOAc, and BuOH) and five phenolics (dihydrokaempferol (1), resveratrol (2), kaempferol-7-O-β-D-glucoside (3), dihydrokaempferol-3-O-α-L-rhamnoside (4), oxyresveratrol (5)) from Smilax c...
Regulatory network analysis of transcription factors, microRNAs, target genes and host genes in human multiple myeloma
In recent years, molecular biologists have achieved great advance in micro RNA (miRNA) and gene investigation about the pathogenesis of multiple myeloma (MM). Existing research data of the transcription factors (TF...