The comparison of dinoprostone and vagiprost for induction of lobar in post term pregnancy: A randomized prospective study
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2015, Vol 5, Issue 1
Abstract
Objective: The aim of study to see the effect of 3mg dinoprostone in induction of labor in comparison to 50mcg vagiprost in post term pregnancies.Methods: A randomized prospective study that attends at bint AL huda hospital from the period of 1stof septmber 2012 to 1stseptmber 2013 where115 patients which need induction of lobar for post term pregnancy that diagnosed by early dating U/S, where randomly divided into 2 groups, the 1stgroup receive dinoprstone 3mg vaginal tablet , the other group receive vagiprost 50mcg vaginal tablet. The mean outcome measures is the time from induction to delivery, the incidence of vaginal delivery within 12 and 24 hours, obstetrical complications & neonatal outcome.Result: The induction to delivery time was significantly shorter ( 12.5 hrsvs 16.3 hrs P < 0.001) in the misoprostol group with less need to second and third dose ( 9% vs 20% P value < 0.05) compared to dinoprostone. With misoprostol more women delivered within 12 hours ( 54.5% vs 46.6% P < 0.01) and nearly all women delivered within 24 hours ( 81.8% vs 66.6% P < 0.05), there was a less need for oxytocin augmentation in the misoprostol group ( 27.2% vs 41.6% P <0.05), In both groups majority of women had vaginal deliveries (83.4% with dinoprostonevs, 81.8% with misoprostol ) and there was no statistically difference between the rate of C/S in both groups. there was difference regard the admission to baby care unit (27.2% in misoprostol vs 8.3% in the dinoprostone group).
Authors and Affiliations
Dr – Nadia Saddam , AI assady
Keywords
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