UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE ASSOCIATED WITH METASTATIC SEMINOMA: A RARE CASE REPORT
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 7
Abstract
Many autoimmune diseases have been reported to be associated with malignancies with an incidence rate of 5%. (1) A 30-year male with recurrent edema of the lips and periorbital area with itching and pain for 6 weeks. He had both extremity weakness with upper back pain for 1 month. H/O loss of weight and appetite for 1 yr. With this clinical picture, a diagnosis of angioedema/dermatomyositis (CTD) was suspected. CPK and CPK-MB within normal limits, antinuclear antibodies + by IF with titre of 1:320 with nucleus-granular pattern suggesting autoantibodies against U1-RNP Antigen/Sm Antigen. USG scrotum- a single testes. MRI-spine revealed multiple peripancreatic, pre- and para-aortic and left supraclavicular lymph nodes with nodules in both lungs. CT Thorax and CT Abdomen showed liver and lung metastasis with periportal and vertebral lymph nodes. FNAC left supraclavicular node-positive for malignant cells, suggestive of metastatic malignant germ cell tumor. Tumor markers-elevated (aFP-180, bHCG- 457.2.
Authors and Affiliations
Gayathri , Radha , Sudha , Krishnakanth , Mahalakshmi
Keywords
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- EP ID EP133617
- DOI 10.14260/jemds/2016/76
- Views 85
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