Neo-adjuvant PIPAC and Systemic Chemotherapy in Management of Synchronous Peritoneal Metastasis From Gastric Cancer
Journal Title: Journal of Clinical Medical Research - Year 2023, Vol 4, Issue 3
Abstract
Introduction: Polycystic Ovarian Disorder (PCOD) is a prevalent endocrine illness in women of reproductive age. It has hormonal abnormalities, irregular menstrual cycles and tiny ovarian cysts. Lifestyle and food affect PCOD development and maintenance, coupled with Peritoneal metastasis from gastric cancer remains a major problem. The aim of our study is a retrospective analysis in two different groups with used PIPAC as neo-adjuvant management of synchronous peritoneal metastasis. Group A: 42 patients received as neo-adjuvant treatment 2 cycles of PIPAC (Doxorubicin 3 mgr/m2, cisplatin 10 mgr/m2) and 6 cycles of neo-adjuvant systemic chemotherapy with FLOT and we performed CRS+HIPEC (with cisplatin 80 mgr/m2, mitomycin 35 mgr/m2) for 90 min and 6 cycles of adjuvant systemic chemotherapy with FLOT. Group B: 26 patients received 4 cycles of neo-adjuvant systemic chemotherapy with FLOT, we performed CRS+HIPEC as Group A and 4 cycles of systemic chemotherapy with FLOT. For patients of Group A, the Median survival time is 46months.Group B patients had a median OS of 36 months. For patients of Group A, the Median Disease Time (DFS) was 37 months. Group B patients had a median DFS of 30 months. For each degree increase in the PCI pre score and for the same treatment group, the PCI posr score increases by 0.573 degrees. Group 2, for the same PCIpre score, have a 163% higher PCI posr score. On patients with singet ring cell adenocarcinoma there is a statistical significance difference in OS for PIPAC group. Patients of group A had a median OS of 26 months. For patients of group B, the median OS was 14 months. Morbidity and mortality in both groups are 53,4% and 4,7% for Group A and 44,5% and 5,5% for Group B respectively. The neo-adjuvant PIPAC with systemic chemotherapy might be a promising approach for patients with peritoneal metastasis from gastric cancer. PIPAC is a safe and well tolerated procedure.
Authors and Affiliations
Bohlooli M, Farmakis D, Saroyan H, Kazemi V, Noskova I, Omid R, Spiliotis J
Keywords
Related Articles
- EP ID EP722226
- DOI http://dx.doi.org/10.46889/JCMR.2023.4307
- Views 41
- Downloads 0
Big Tobacco, Cigarettes and the Foundation of Duke University
Duke University was founded in 1930 primarily due to funds generated from James B Duke’s tobacco business. Duke achieved great financial wealth primarily due to the early application of machine rolled cigarettes, as oppo...
Effects of Progressive Physiotherapy Along with or Without Active Bed Rest at Hospital for the Management of Chronic Low Back Pain (LBP) Patients in Bangladesh
Background: Low Back Pain (LBP) is a significant health condition globally suffered by the middle and older aged population due to its impact on work disability, absenteeism and costs. Physiotherapy with active rest and...
The Importance of Dietary and Lifestyle Changes in Health Improvement
Nowadays, life expectancy has become a global phenomenon. Because of this, the concept of “Healthy Longevity” has attracted attention in recent years, as it encompasses not only living a long life but also living a life...
Breast-Implant Associated Anaplastic Large Cell Lymphoma: A Case Report
The Food and Drug Administration (FDA) released a statement in the beginning of 2017 regarding a rare cancer, Anaplastic Large Cell Lymphoma (ALCL) that has been related to textured breast implants and resulted in nine...
The Genetic Discrepancy-Lynch Syndrome
Lynch syndrome is a frequently discerned hereditary cancer syndrome demonstrating the occurrence of colorectal carcinomas in around 80% subjects and endometrial cancers in nearly 60% individuals. Lynch syndrome is acco...