Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 2
Abstract
Background: Extensive previous research has suggested a role for serotonin (5-HT) in learning and memory processes, both in healthy individuals and pathological disorders including depression, autism and schizophrenia, most of which have a developmental onset. Since 5-HT dysfunction in brain development may be involved in disease etiology, the present investigation assessed the effects of neonatal 5-HT depletion on spatial learning and memory in the Morris water maze (MWM). Methods: Three days old Sprague-Dawley rats were pretreated with desipramine (20 mg/kg) followed by an intraventricular injection of the selective 5-HT neurotoxin 5,7-dihydroxytryptamine (5,7-DHT, 70 μg). Three months later rats were tested in the MWM. Results: Despite a severe and permanent decrease (80-98%) in hippocampal, prefrontal and striatal 5-HT levels, treatment with 5,7-DHT caused no spatial learning and memory impairment. Conclusions: Limited involvement of chronic 5-HT depletion on learning and memory does not exclude the possibility that this neurotransmitter has an important neuromodulatory role in these functions. Future studies will be needed to identify the nature of the compensatory processes that are able to allow normal proficiency of spatial learning and memory in 5-HT-depleted rats.
Authors and Affiliations
Agnieszka Piechal, Kamilla Blecharz-Klin, Edyta Wyszogrodzka, Paulina Kołomańska, Paweł Krząścik, Wojciech Kostowski, Ewa Widy-Tyszkiewicz, Małgorzata Filip, Roman Stefański
Keywords
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