Neoplasms of other organs associating gastric and colorectal cancer in own observation
Journal Title: Gastroenterologia Polska - Year 2008, Vol 15, Issue 1
Abstract
Introduction: Synchronous and/or metachronous multiple neoplasms in humans have been observed for many years. Increasing incidence of multiple neoplasms has been attributed to genetic predisposition, impaired immune state, chemicals (cancerogens) and antineoplastic therapy in the past (radiotherapy, chemotherapy). Although special surveillance is required in patients with genetic predisposition to multiple neoplasms, it seems to be necessary in people with so called sporadic malignancy as well with the aim of early detection of a successive primary neoplasm. Aim of study:To assess the occurrence of multiple primary malignancies, both synchronous and metachronous, their localization, age at onset and interval time between the onset of the first and successive primary neoplasms in patients hospitalized in Gastroenterology and Hepatology Department of Wrocław Medical University within the last 11.5 years. Special attention was paid to the origin of primary neoplasms associating gastric and colorectal cancer. Material and methods: From 16 550 history records of patients hospitalized in our Department in the period from January 1996 to June 2007 the records of patients in whom anamnesis and diagnostic tests performed during hospitalization indicated the occurrence of two and more primary malignancies in the course of life were chosen and thoroughly analyzed. Additionally, patients with gastric and colorectal cancer we re separated and associating neoplasms were analyzed. Results: In our study patients with multiple primary neoplasms (n=34) constituted a small percentage (3.2%) of all patients hospitalized with neoplastic disease. Among them 77 primary malignancies of different origin were diagnosed all together. In females gastric cancer coexisted most frequently with breast cancer and then with malignancies originating from uterus, whereas in males with colorectal adenocarcinoma. In our observation in females colorectal cancer was associated most frequently with breast cancer and then with malignancies originating from uterus, ovary, kidney and thyroid gland. In males colorectal cancer was associated mainly with gastric cancer and carcinoma of the larynx, then with prostate cancer and primary tumors of the kidney. Conclusions: Presented data confirm the need of a life-long observation of patients with the history of malignancy, not only being members of families with increased riskof neoplastic disease and not only because of the risk of recurrence and metastases, but also because of the riskof a successive primary neoplasm. Such surveillance could allow for earlier detection of new neoplastic sites, increase treatment efficacy and improve prognosis leading to the better outcome in patients with multiple primary malignancies.
Authors and Affiliations
Jarosława Semianów-Wejchert, Agata Arlukiewicz, Agnieszka Lewandowska, Paweł Petryszyn, Abdulhabib Annabhani, Battssengel Rentsen, Leszek Paradowski
Keywords
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