Indeterminate colitis – diagnostic difficulties in differentiation of inflammatory bowel disease
Journal Title: Gastroenterologia Polska - Year 2006, Vol 13, Issue 5
Abstract
Because of the lack of a single gold standard for colitis ulcerosa and Crohn’s disease diagnosis, differentiation is based on clinical, radiographic, endoscopic findings and the diagnosis is confirmed by histopathologic assessment. Even after combining all available modern methods the exact diagnosis still remains inconclusive in approximately 10% of patients and these cases are classified as indeterminate colitis (IC). The term IC is considered by some authors as a temporary diagnosis, which can be changed during follow-up. However, the term of IC has been evolved recently to the conclusion that these patients may reveal a specific, separate subtype of inflammatory bowel disease (IBD). With high progress in our knowledge about immunologic background of IBD, present studies are mainly focused on finding markers as noninvasive and useful tools. Perinuclear antineutrophil cytoplasmic antibodies (pANCA), which are characteristic for ulcerative colitis and anti-Saccharomyces cerevisiae antibodies (ASCA) widely found in Crohn’s disease, are negative in IC patients. Perhaps the IC status will be supported by this specific antibodies pattern. The aim of our paper is to present the term IC, which is commonly used in current studies. Moreover, in our study we have tried to sum up the diagnostic difficulties in differentiation of IBD subtypes, mainly in histopathologic assessment.
Authors and Affiliations
Anna Mokrowiecka, Agnieszka Wierzchniewska-Ławska, Ewa Małecka-Panas
Keywords
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