NEPHROPROTECTIVE ACTIVITY OF PLUMERIA RUBRA AGAINST CISPLATIN INDUCED NEPHROTOXICITY IN EXPERIMENTAL RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2019, Vol 11, Issue 4
Abstract
Objective: The current study was designed to evaluate the protective effect of standardized hydroalcoholic extract of Plumeria rubra (HAEPR) against cisplatin-induced nephrotoxicity in Wistar rats. Methods: HAEPR was administered orally at 3 dose levels (100,200,400 mg/kg). Vitamin E (250 mg/kg) was used as a Standard nephroprotective agent. The kidney function test (estimation of serum creatinine, albumin, blood urea nitrogen) oxidative stress study (estimation of superoxide dismutase, malondialdehyde activity) and histological examination of kidneys was conducted. Results: The efficacy of HAEPR was compared with Cisplatin (CP) treated group. Serum creatinine and BUN was significantly (p<0.01) elevated in CP-treated group compared to the control group. HAEPR (100,200 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.01) decreased the serum creatinine and BUN levels. CP treated group exhibited significant (p<0.01) decrease in albumin when compared to control. Significant (p<0.01) increase in the serum albumin level was found in HAEPR (100,200 mg/kg) and Vitamin E (250 mg/kg) compared to CP group. Significant (p<0.01) decrease in the activity of SOD was observed in the CP group as compared to control. HAEPR (100 and 200 mg/kg) and Vitamin E (250 mg/kg) significantly (p<0.01) increased SOD levels. HAEPR (400 mg/kg) significantly (p<0.05) increased SOD levels. HAEPR (100,200,400 mg/kg) significantly (p<0.01) decreased MDA levels as compared to CP group. Histopathological examination of the kidneys showed that HAEPR markedly ameliorated Cisplatin-induced renal tubular necrosis. An extract was found effective at all doses, although low dose (100 mg/kg) was found to be more effective and comparable with the standard group (Vitamin E 250 mg/kg). Conclusion: Present investigation revealed that HAEPR resulted in attenuation of Cisplatin-induced renal damage in rats.
Authors and Affiliations
A. V. YADAV, C. D. UPASANI
Keywords
Related Articles
- EP ID EP565409
- DOI 10.22159/ijpps.2019v11i4.31561
- Views 59
- Downloads 0
DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING RP-HPLC METHOD FOR THE DETERMINATION OF VALSARTAN
Objective: A stability indicating RP-HPLC method was developed and validated for the determination of Valsartan using Telmisartan (10 µg/ml) as the internal standard.Methods: In this procedure Phenomenex ODS C-18(250×4...
SERUM ANTI-ZONA PELLUCIDA ANTIBODIES IS CORRELATED WITH ESTRADIOL LEVEL IN WOMEN WITH IN VITRO FERTILIZATION FAILURE
Objective: In vitro fertilization (IVF) is one of the several assisted reproductive technologies (ART) used to aid infertile couples to conceive a child. Many factors affecting the rate of success of IVF cycle. The aim o...
EVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF PELLIONIA HEYNEANA WEDD. LEAF ETHANOLIC EXTRACT ON CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN WISTAR RATSEVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF PELLIONIA HEYNEANA WEDD LEAF E
Objective: The aim of the study was to investigate the antioxidant and hepatoprotective activity of Pellionia heyneana Wedd. leaf ethanolic extract.Methods: The antioxidant potential of the extract was studied by DPPH an...
PROTEINACEOUS COMPOUNDS FROM FRAGARIA ANANASSA FRUIT ATTENUATES PARAQUAT INDUCED PARKINSON LIKE LOCOMOTOR AND MITOCHONDRIAL ALTERATIONS IN ZEBRAFISH
Objectives: To assess the Parkinson like locomotor and mitochondrial alterations, associated with the exposure of paraquat (PQ), in vivo preventive effect of proteinaceous compounds extracted from Fragaria ananassa fruit...
EFFECTS OF SOLVENT POLARITY ON SOLVATION FREE ENERGY, DIPOLE MOMENT, POLARIZABILITY, HYPERPOLARIZABILITY AND MOLECULAR REACTIVITY OF ASPIRIN
Objective: The aim of the study is to explore the effects of solvent polarity on solvation free energy, dipole moment, polarizability, first order hyperpolarizability and different molecular properties like chemical hard...