Nephrotoxicity effects of Khat (Catha edulis) on mice when administered orally

Journal Title: The Journal of Phytopharmacology - Year 2017, Vol 6, Issue 1

Abstract

Renal problems are currently on increase worldwide. Some factors suspected to be the cause of the renal problems are drug abuse. Hence, this study investigated possible renal toxicity effect of Khat in male albino mice. Khat alkaloids were extracted from fresh Khat shoots and leaves. The Khat extract were administered orally through intubation. Accordingly, forty- five albino mice (20 – 25g) were distributed randomly into nine groups (n = 5). Negative controls (NCs) received purely distilled water. Positive controls (PCs) received indomethacin at a dosage of 2mg/Kg/day as a twice dose per day. Test groups received Khat extract administered in combination of 2ml tea, 2ml water, 2ml milk, 2ml coffee, 2ml coke, 2g patico sweet and 2g groundnut. To each test group Khat extract was administered at a dosage of 2000mg/Kg/day for four weeks. Blood samples were collected from all animals for biochemical analysis after four weeks which included the renal function tests such as serum creatinine and blood urea nitrogen levels. The histological and cytological studies were done using H&E staining technique. There was an increased level of renal biochemical markers in all albino mice serum exposed to Khat extract. There was a significant different between levels of renal biochemical enzymes biomarkers at p<0.05. There were signs of adverse effects of Khat on kidney of mice.

Authors and Affiliations

Godfrey Mutuma Gitonga, Joseph Ngeranwa, Alex King’ori Machocho, Daniel Gaichu Muthee, Rodgers Kimutai, Ann Wanjiru Gitonga

Keywords

Related Articles

Phytochemical profile and antimicrobial potential of methanolic extracts of bark and leaf of Quassia indica (Gaertn.) Nooteb

The study comprises the results of phytochemical analysis and antimicrobial evaluation of extracts from bark and leaf of Quassia indica (Gaertn). Nooteb. – a medicinal plant used in traditional healing owing to its ana...

Exploratory and anxiety potentials of aqueous extract of Phragmanthera capitata

Aim: To evaluate the exploratory and anxiety potentials of aqueous extract of Phragmanthera capitata (AEPC) in Wistar rats using hole-board paradigm. Materials and Methods: Healthy rats were randomized into 5 groups. G...

Standardization of Naga Bhasma prepared by two different Bhavana Dravya

Naga Bhasma is one of the herbo-metallic preparations used in Ayurveda and claimed to possess broad spectrum of therapeutic efficacy. The Standard manufacturing Procedures of Naga Bhasma prepared by two methods by chan...

Kalanchoe pinnata aqueous extract safety and potential cardioprotective effects in isoprenaline treated rats

Introduction: Kalanchoe pinnata (Crassulaceae) aqueous extract antihypertensive property has been proven. This study aimed to evaluate the safety and potential cardioprotective effects of the extract in isoproterenol t...

Influence of microwave assisted extraction on antioxidant and antiplasmodial activities of Trichilia roka extracts

Antiplasmodial and antioxidant activities of extracts derived from Trichilia roka (Chiov) (Meliaceae) root bark were determined respectively in vitro and using two methods as well as 1,1-diphenyl-2-picrylhydrazyl radica...

Download PDF file
  • EP ID EP49712
  • DOI -
  • Views 176
  • Downloads 0

How To Cite

Godfrey Mutuma Gitonga, Joseph Ngeranwa, Alex King’ori Machocho, Daniel Gaichu Muthee, Rodgers Kimutai, Ann Wanjiru Gitonga (2017). Nephrotoxicity effects of Khat (Catha edulis) on mice when administered orally. The Journal of Phytopharmacology, 6(1), -. https://europub.co.uk/articles/-A-49712