Nephrotoxicity effects of Khat (Catha edulis) on mice when administered orally

Journal Title: The Journal of Phytopharmacology - Year 2017, Vol 6, Issue 1

Abstract

Renal problems are currently on increase worldwide. Some factors suspected to be the cause of the renal problems are drug abuse. Hence, this study investigated possible renal toxicity effect of Khat in male albino mice. Khat alkaloids were extracted from fresh Khat shoots and leaves. The Khat extract were administered orally through intubation. Accordingly, forty- five albino mice (20 – 25g) were distributed randomly into nine groups (n = 5). Negative controls (NCs) received purely distilled water. Positive controls (PCs) received indomethacin at a dosage of 2mg/Kg/day as a twice dose per day. Test groups received Khat extract administered in combination of 2ml tea, 2ml water, 2ml milk, 2ml coffee, 2ml coke, 2g patico sweet and 2g groundnut. To each test group Khat extract was administered at a dosage of 2000mg/Kg/day for four weeks. Blood samples were collected from all animals for biochemical analysis after four weeks which included the renal function tests such as serum creatinine and blood urea nitrogen levels. The histological and cytological studies were done using H&E staining technique. There was an increased level of renal biochemical markers in all albino mice serum exposed to Khat extract. There was a significant different between levels of renal biochemical enzymes biomarkers at p<0.05. There were signs of adverse effects of Khat on kidney of mice.

Authors and Affiliations

Godfrey Mutuma Gitonga, Joseph Ngeranwa, Alex King’ori Machocho, Daniel Gaichu Muthee, Rodgers Kimutai, Ann Wanjiru Gitonga

Keywords

Related Articles

Consequence of concurrent use of chloroquine and hydroalcoholic extract of Balanites aegyptiaca and leaf leatx of Aloe camperi

Prescription and/or over the counter medications when taken together with certain foods or herbal substances, leads to either increase or decrease a drug’s therapeutic out comes or adverse effects. It has been reported...

Role of Dhoopan Karma and Gauradya Ghrita in the management of Dushta Vrana (infected wound)

Ayurveda is that which deals with good, bad, happy and unhappy life, its promoters and non-promoters, measurement and nature. Shalya Tantra is a specialized branch of Ayurveda in which Surgical, Medicinal and Parasurgi...

Experimental study on Operculina turpethum in STZ induced diabetic neuropathy, neurodegeneration and cardiovascular complications

Neuropathy and Cardiac complications are the most common trouble in diabetes mellitus with progressive damage due to complex pathogenesis. Many conventional pharmacological agents were withdrawn from clinical studies e...

Effect of aqueous extract of Talinum triangulae (water leave) in lead- induced chromosomal aberration

Phytomedicine is a subject that is now gaining relevance worldwide aiding treatment for diseases that were once incurable among folks in which genotoxicity is a prominent one. The present study was designed to examine...

Antiplasmodial and antidiarrhoeal activities of Dicliptera verticillata leaf extract

Dicliptera verticillata (Forssk) Ch. (Acanthaceae) (leaf) is used as a traditional medicine for the treatment of malaria and diarrhoea in Burkina Faso and among the Ibibios of southern Nigeria. This study was aimed at...

Download PDF file
  • EP ID EP49712
  • DOI -
  • Views 174
  • Downloads 0

How To Cite

Godfrey Mutuma Gitonga, Joseph Ngeranwa, Alex King’ori Machocho, Daniel Gaichu Muthee, Rodgers Kimutai, Ann Wanjiru Gitonga (2017). Nephrotoxicity effects of Khat (Catha edulis) on mice when administered orally. The Journal of Phytopharmacology, 6(1), -. https://europub.co.uk/articles/-A-49712