Neuro-fuzzy Models as an IVIVR Tool and Their Applicability in Generic Drug Development
Journal Title: The AAPS Journal - Year 2014, Vol 16, Issue 2
Abstract
The online version of this article (doi:10.1208/s12248-014-9569-8) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Jerneja Opara, Igor Legen
Keywords
Related Articles
- EP ID EP681065
- DOI 10.1208/s12248-014-9569-8
- Views 278
- Downloads 0
Pharmacokinetics/pharmacodynamics and the stages of drug development: Role of modeling and simulation
Pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation (M&S) are well-recognized powerful tools that enable effective implementation of the learn-and-confirm paradigm in drug development. The impac...
Cellular uptake and concentrations of tamoxifen upon administration in poly(ε-caprolactone) nanoparticles
Purpose: In an attempt to increase the local concentration of tamoxifen in estrogen receptor positive breast cancer cells, we have prepared and characterized poly (ε-caprolactone) (PCL) nanoparticle formulation....
k Opioids as potential treatments for stimulant dependence
Stimulant abuse is a major problem in the United States and the development of pharmacological treatments for stimulant abuse remains an important therapeutic goal. Classically, the “dopamine hypothesis”...
Development, Validation, and Clinical Implementation of an Assay to Measure Total Antibody Response to Naglazyme® (Galsulfase)
Naglazyme® (galsulfase, rhASB) was developed as enzyme replacement therapy for mucopolysaccharidosis type VI. Naglazyme generated an IgG antibody response in most patients. To better characterize Naglazyme immuno...
Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin
The transdermal delivery of buspirone hydrochloride across hairless mouse skin and the combined effect of iontophoresis and terpene enhancers were evaluated in vitro using Franz diffusion cells. Iontophoretic delivery wa...