Neuro-Histo-Morphological Changes Seen Associated with Learning & Memory in Hippocampal Neurons of Rats Administrated with Catha edulis
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
The tender Catha edulis leaves(Khat) have stimulatory properties due to the presence of alkaloid called cathinone, which is known to have a stimulating effect at lower dosages and can act as depressant if consumed at higher quantities. This study was aimed at assessing the effect of khat leaf extract on learning and memory of the rats. The study was conducted in 40 adult male Wistar rats. The rats were randomly assigned to eight groups, four groups each for RA Maze and T MAZE trails respectively. The calculated dosages were 100mg/kg Bwt (T1), 200 mg/kg Bwt (T2), 300mg/kg Bwt (T3) and control group were provided with normal saline. At the end of the experiment the rats were sacrificed and the hippocampus CA3 region of brain was identified and thereafter processed for rapid Golgi staining. The data obtained were analyzed using descriptive statistics and the means compared using Duncan’s Multiple Range Test (P<0.05). The results show that the rats in both the experimental groups showed better ( P<0.05) learning abilities at T2 diet, where as those reared on T3 diet showed learning disorders with however no differences were recorded among those in T1 and control diets. The results of the dendritic branching counts supplement the above findings with lowest counts recorded among the rats receiving T3 dosages and highest among those reared on T2 dosages. In conclusion, at higher dosages, Khat extract leads to deterioration of learning and memory while at medium dosages it has a stimulating effect on the learning and memory.
Authors and Affiliations
Manoj Kollukkad Mani
Keywords
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- EP ID EP572204
- DOI 10.9790/0853-1804036472.
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