Neurodevelopmental assessment of neonates with congenital hypothyroidism in a tertiary care center
Journal Title: Indian Journal of Child Health - Year 2017, Vol 4, Issue 3
Abstract
Background: Thyroid hormones play a crucial role in early neurodevelopment so that untreated severe congenital hypothyroidism (CH) results in neurological and psychiatric deficits, including intellectual disability, spasticity, and disturbances of gait and coordination. Objective: The aim of this study is to assess the neuromotor and neurocognitive development of babies at 12 months of age who are diagnosed to have CH and initiated on thyroxine treatment at birth. Furthermore, to estimate the occurrence of CH among babies delivered in our hospital through thyroid screening. Study Design: This was a descriptive study. Setting: The study was conducted in Sree Gokulam Medical College Hospital and Research Foundation, a tertiary care center, located in Trivandrum, Kerala. Participants: All babies delivered in the hospital during the study period and neonatal screening was done for CH. Methods: Cord blood was collected as the direct flow of blood from cord, labeled and sent to laboratory from delivery room for analysis (by chemiluminescent assay) of thyroid-stimulating hormone (TSH). Babies with cord blood TSH level ≥20 uIU/ml were repeated at 72 h of age for venous TSH and FT4 level. Venous TSH level ≥20 uIU/ml with low FT4 (below normal range for age) was considered as abnormal and initiated on treatment before discharge from the hospital. These babies were followed till 12 months of age for neurodevelopmental assessment. Results: The occurrence of CH among babies delivered in our hospital was 0.6 in 100 live births. Neurodevelopmental assessment of babies with CH on follow-up has shown normal neuromotor and neurocognition at 12 months of age with early detection and prompt initiation of L-thyroxine at a higher dose range within 5 days of age. Conclusion: In our study, early detection and initiation of treatment in infants with CH have shown normal neuromotor and neurocognitive development at 12 months of age.
Authors and Affiliations
Jemila James, P M C Nair, Lalitha Kailas, Sreedevi Narayanan
Keywords
Related Articles
- EP ID EP456519
- DOI -
- Views 81
- Downloads 0
Dengue hepatic severity score: A glimmer to the clinician
Introduction: Recent studies from India and Thailand show that dengue infection was the most compelling cause of acute hepatic failure in children contributing to 18.5% and 34.3%, respectively, and till now, there is no...
Clinical and laboratory profile of children admitted with measles in a tertiary care teaching hospital
Background: Measles is a vaccine-preventable viral illness associated with substantial childhood morbidity and mortality. Recently, changing trends in the occurrence of measles are noted like incidence in younger infants...
Study to evaluate the effectiveness of coagulation factor concentrate prophylaxis in children with severe hemophilia
Objective: To evaluate the effectiveness of prophylaxis with coagulation factor concentrates VIII/IX (FVII/IX) in children with severe hemophilia A/B, respectively. Materials and Methods: Retrospective observational stud...
Correlation between umbilical venous blood gas at birth and comorbidities in preterm babies - A cohort study
Background: Umbilical cord blood gas analysis is a useful tool in predicting short-term outcomes in term infants. The value of umbilical venous blood gas analysis in predicting short-term outcomes in preterm infants is l...
Tracheostomy among pediatric patients: A review
Tracheostomy is a surgical procedure which has been performed since ancient time. Tracheostomy is a life-saving surgical procedure done among critically sick patients. Children with airway compromise often require trache...