Neuroimaging in Cycloserine Induced Neurotoxicity: A Rare Case Report
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2018, Vol 7, Issue 2
Abstract
Tuberculosis (TB) is an infectious disease. There is an increasing burden of Drug Resistant TB (DR-TB) which is not only difficult to treat and associated with adverse events during its treatment. Cycloserine is a broad spectrum antibiotic used as a second-line agent for DR-TB therapy. Psychiatric adverse drug reactions are well known. Neurotoxicity with the use of supplemental pyridoxine is rarely reported. We report a case of young boy who developed tilting of body to one side during therapy for DR-TB which included cycloserine. Magnetic Resonance Imaging (MRI) of the brain showed reversible bilateral symmetrical (T2/FLAIR) hyperintensity in dentate nuclei. Clinical and MRI findings were consistent with cycloserine toxicity. Symptoms resolved on withdrawing the drug. MRI findings showed marked reversibility.
Authors and Affiliations
Sandeep Sharma, Prajay Lunia, Unnati Desai
Keywords
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