NEUROINFLAMMATION IN THE PATHOGENESIS OF NEURODEGENERATIVE DISEASE. A RATIONAL FRAME WORK FOR THE SEARCH OF NOVEL THERAPEUTIC APPROACH
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 5
Abstract
Neuroinflammation appears to occur as a consequence of a series of damage signals, including trauma, infection, oxidative agents, redox iron, oligomers of τ and β-amyloid, etc. In this context, our theory of Neuroimmunomodulation focus on the link between neuronal damage and brain inflammatory process, mediated by the progressive activation of astrocytes and microglial cells with the consequent overproduction of proinflammatory agents. Here, we discuss about the role of microglial and astrocytic cells, the principal agents in neuroinflammation process in the development of neurodegenerative diseases.
Authors and Affiliations
Ashish Kumar Verma
Keywords
Related Articles
- EP ID EP649131
- DOI -
- Views 160
- Downloads 0
TOXICITY OF DIEMETHOATE TO THE FRESHWATER FISH RASBORA DANICONIUS ON HISTOLOGY OF GILL
In the present investigation freshwater fish, Rasbora daniconius was exposed to sub lethal concentrations of dimethoate at Lc50 of 96 hours i.e. 9.136 ppm to determine histopathological changes in the gill morphology. Th...
EFFECT OF HAMSTRING EXTREMITY STRETCHING EXERCISES ON BALANCE
Balance is the ability to maintain the body’s centre of mass (COM) within the limits of the base of support. Young adults are having sedentary lifestyle now a days which may affect ther flexibility of muscles the main ob...
A PILOT STUDY ON THE EFFICACY OF VYOSHADI VARTI IN THE MANAGEMENT OF ARMA (PTERYGIUM)
Arma is a disease of Shuklamandala of eyes in which a wing like growth develops gradually from either Kaneenika Sandhi (inner canthus) or Apanga Sandhi (outer canthus) towards the cornea. It can be correlated to Pterygiu...
JALAUKA (LEECH)…THE PARA SURGICAL INSTRUMENT
Panchkarma is globally accepted and famous branch of Indian system of medicines i.e. Ayurveda. Raktamokshan has been described as a part of shodhan by Sushruta. Jalaukavacharan karma is the part of Raktamokshana .In pres...
LETRATURE REVIEW OF SIROTPATA WITH ITS MODERN ASPECTS
Ayurveda is science of life and its basic aim is to maintain health of human beings and care of illness. It is one of the oldest scientific medical systems in the world, with long record of clinical experience. Netra (ey...