Neuromodulation and Non-Pharmacological Treatment of Migraine
Journal Title: Neuro – Open Journal - Year 2016, Vol 3, Issue 1
Abstract
Migraine is a chronic brain disorder that is believed to be due to dysfunction of the brain and brainstem that result in dysmodulation of sensory processing of the head and vascular tone. The exact pathomechanism of migraine is not known but some genes including mutations in the sodium and calcium channels and Na+/K+ pump have been implicated in migraine with aura.1-8 Several drugs are currently used in the acute and preventive treatment of migraine. These include the non-steroidal anti-inflammatory drugs, the triptan family, anti-epileptic drugs, beta-blockers, calcium channel blockers, steroids, and recently antibodies against calcitonin gene-related peptide (CGRP) or its receptor among other drugs.5,9 Some other drugs are under investigation and the CGRP receptor antagonists (the gepant family drugs), were discontinued although other drugs in this category are still under investigation.10-16 However, there are some medically intractable headaches or unsatisfactory patient management or medications are poorly tolerated, therefore, additional treatment options might be helpful.
Authors and Affiliations
Mohtashem Samsam
Keywords
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- EP ID EP552547
- DOI 10.17140/NOJ-3-e006
- Views 130
- Downloads 0
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