Endovascular treatment of Stroke: Historical Perspective
Journal Title: Neuro – Open Journal - Year 2015, Vol 2, Issue 2
Abstract
Effective acute ischemic stroke therapy hinges on rapid restoration of blood flow to the ischemic tissue. Since the National Institute of Neurological Diseases and Stroke r-tPA study,1 intravenous fibrinolytic therapy in appropriately selected patients has been the primary method used to open the vessels and improve neurological outcome from stroke. The intravenous administration allowed for widespread dissemination of the technique, since therapy could be started very rapidly after the diagnosis is made. However, successful treatment with r-tPA requires careful patient selection and adherence to strict inclusion and exclusion criteria. As a result, there is a significant number of patients who could not receive the therapy. Even though significantly better than placebo for most stroke patients, some still suffered a poor outcome in spite of therapy. This raised the question whether there could be a way to directly apply the fibrinolytic agent to the occlusive thrombus with catheter-based techniques in an effort to more effectively treat large vessel occlusions.
Authors and Affiliations
John P. Deveikis
Keywords
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- EP ID EP553081
- DOI 10.17140/NOJ-2-e003
- Views 123
- Downloads 0
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