Toxin-Induced Parkinson’s Disease Models
Journal Title: Neuro – Open Journal - Year 2017, Vol 4, Issue 1
Abstract
The Topic “Toxin-Induced Parkinson’s Disease Models’ includes articles on experimental neurotoxic chemicals models of Parkinson’s Disease (PD). The model toxicants with differing chemical structures recapitulate PD owning to their action on multiple molecular targets. These reports have provided with deeper understanding on the neurodegenerative events associated with the progressive disease. Several toxin-based models are developed in an attempt to experimentally mimic dopaminergic neurodegeneration, oxidative stress, cytoplasmic inclusions, proteasome dysfunction, altered protein trafficking, calcium overload and potentially mapping the events in the PD pathology. This spectrum includes research reports and reviews that discuss neurotoxin-based models (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 6-OHDA, rotenone, paraquat) that have greatly contributed to unravel the key mechanisms of neuronal cell death. In relevance to PD in humans, toxin-induced PD models have provided for observable behavioral deficits (motor and non-motor features). Moreover, the etiologic specific insights gained into the disease with the chemical modelling of PD has aided to screen/develop novel therapies.
Authors and Affiliations
Gokul Krishna
Keywords
Related Articles
- EP ID EP552531
- DOI 10.17140/NOJ-4-e007
- Views 134
- Downloads 0
Clinical Data Associated With the Therapeutic Response to Glatiramer Acetate in Multiple Sclerosis Patients
Background: The increasing appearance of new drugs is making more difficult the choice of treatment in multiple sclerosis. According to different criteria, between 20 to 50% of the patients with multiple sclerosis (MS) t...
Chronic Subdural Haematoma: Systematic Review Highlighting Risk Factors for Recurrent Bleeds
Introduction: Chronic subdural haematoma (CSDH) is one of the commonest forms of intracranial haemorrhage. Surgical drainage of CSDH is a routine operation in the modern neurosurgical practice which has shown to be the m...
The Diagnostic Role of Neuromuscular Ultrasound in Chronic Inflammatory Demyelinating Polyneuropathy
The immune-neuropathies are a heterogenous group of peripheral nerve disorders. Their diagnostic classification is mainly based on the documentation of the distribution pattern of peripheral nerve impairment and the resu...
Neurovascular Conflicts of Cerebellopontine Angle: A Review of the Literature
The pathology of the cistern of the cerebellopontine angle is primarily the disease of the nervous and vascular structures that it contains and of the meninges that line it. It appears by the Trigeminal Neuralgia (TN), H...
Targeting Calcitonin Gene-Related Peptide and its Receptor by Monoclonal Antibody, New Developments in the Prevention of Migraine
Migraine is a chronic headache disorder with an unknown pathophysiology. Research in the past decade has shown that to be a brain disorder, a dismodulation of sensory processing affecting vascular tone and pain1-3 but si...