Neuropathic pain due to chronic idiopathic axonal neuropathy: fast pain reduction after topical phenytoin cream application
Journal Title: Open Journal of Pain Medicine - Year 2018, Vol 2, Issue 1
Abstract
Pain due to chronic idiopathic axonal polyneuropathy (CIAP) is often treated with therapies based on general neuropathic pain guidelines, which are mainly developed with randomized clinical trials having valuated treatments for painful diabetic neuropathy (PDN) and post-herpetic neuralgia. No clinical trial studying treatments for patients with painful CIAP has been yet executed, thus only extrapolation of the value of treatments from other neuropathic pain fi elds is possible. Clearly, the pathogenesis and pathophysiology of CIAP will be quite different from that of PDN. Many CIAP patients complain of intolerable side effects of current analgesic medication. In order to help those patients, we developed a treatment-regime consisting of the supplement palmitoylethanolamide and topical formulations of analgesics. This combination is rarely complicated by side effects. One of our most recent topical formulation we developed contains 10% phenytoin, a broad acting voltage-gated sodium-channel blocker. Phenytoin 10% cream can also be used as a stand-alone therapy as we will discuss.
Authors and Affiliations
Hesselink Jan M Keppel, Kopsky David J
Keywords
Related Articles
- EP ID EP559503
- DOI 10.17352/ojpm.000008
- Views 49
- Downloads 0
Neuropathic pain due to chronic idiopathic axonal neuropathy: fast pain reduction after topical phenytoin cream application
Pain due to chronic idiopathic axonal polyneuropathy (CIAP) is often treated with therapies based on general neuropathic pain guidelines, which are mainly developed with randomized clinical trials having valuated treatme...
Pain is a Prevalent Symptom of Adolescents at Diagnosis with Postural Orthostatic Tachycardia Syndrome
Pain is often endorsed by patients with postural orthostatic tachycardia syndrome (POTS). A retrospective chart analysis of adolescents diagnosed with PTS from January 2014-December 2015 at the pediatric cardiology clini...
Chronic Pain after Laparoscopic Inguinal Hernia Repair Depends on Mesh Implant Features: A Clinical Randomised Trial
Chronic pain is a severe complication of mesh-based inguinal hernia repair. In this prospective, clinical, randomized, double-blind study we investigated the biocompatibility of three different meshes and their influence...
Parasternal Block with Two Different Concentration of Ropivacaine for Post-Operative Analgesia in Patient Undergoing Coronary Artery Bypass Grafting: A Randomized Double Blind Controlled Trial
Background: Postoperative sternal pain is one of the most important factors affecting patients’ quality of life during the early post-operative days. Optimal pain management after cardiac surgery improve comfort and well...
Kambo: A ritualistic healing substance from an Amazonian frog and a source of new treatments
Kambo is the name of a complex mixture of a number of bioactive peptides, secreted via the skin of a tropical frog, Phyllomedusa bicolor. Since centuries this secretion is harvested from the living animal by members of t...