NEUROPHARMACOLOGICAL EXPLORATION OF THUJA OCCIDENTALIS LINN.
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
In present study, oral administration of 100, 200 and 400 mg/kg doses of the aqueous extract of Thuja occidentalis Linn in rats and mice were evaluated for its anxiolytic, nootropic, anticonvulsant and motor coordination activity by using different animal models. The number of entries as well as the duration of stay in the open arms significantly increased (***p<0.001) in Elevated plus-maze test and in Open field test showed significant (*p<0.5, ***p<0.001) increase of open field Ambulation, Rearing, Self grooming activity at centre in dose dependent manner when comparison to vehicle treated rats, moreover, the open field faecal dropping was also decreased that indicate anxiolytic activity of extract. Significant retention and recovery as compare to control group has been recorded in scopolamine induced amnesia that support nootropic activity of extract. In Pentylenetetrazole (PTZ) - induced seizures, extract dose dependently inhibited the incidence of convulsions and significantly (*p<0.5, **p<0.01, ***p<0.001) delayed the onset of spasm and clones in PTZ treated mice compare to vehicle treated mice. Significant (***p<0.001) motor in-coordination and increased in immobility time was recorded in case of Rota rod test and Tail suspension test respectively that indicate CNS depression activity of the extract. On the basis of these investigations, we may partially conclude that aqueous extract of Thuja occidentalis Linn aerial part can not recommend to patients in day time or before bed due to its CNS activity, but it could be a potent anxiolytic, nootropic, anticonvulsant and CNS depressant for next generation.
Authors and Affiliations
Lokesh Deb , Amitabha Dey , Sachin Agrawal , Avijeet Jain
Keywords
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