Neurophysiological Correlates of Event Related Potential (P300 Wave) in Children with Attention Deficit Hyperactivity Disorder
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 3
Abstract
Abstract: P300 wave is an event related potential (ERP) component elicited in the process of decision making, it is considered as endogenous potential. The present study was designed to evaluate the neurocognitive entrained attentional mechanisms that are stimulus – locked in ADHD children in terms of neural dynamics of P300 wave through assessing and comparing the amplitude (microvolt) and latency (millisecond) of endogenous ERP – P300 wave on auditory oddball task in ADHD and healthy controls. The auditory oddball paradigm consisted of frequent (high tone) and target (low tone) stimuli spread through the domains of active tasks, wherein the participants had to count the number of target low tone stimuli. The latency values of peaking of ERP in milliseconds (ms) across the central EEG electrode lead pairs of Fz and Cz were observed to be of higher magnitude in children suffering from ADHD as compared to that observed in normal healthy control with P values of 0.001 [S] and 0.002 [S], no statistically significant difference could be appreciated in the amplitude values of the ERP wave form so studied in both the comparative groups of ADHD and normal healthy children.
Authors and Affiliations
Dr. Kavita Yadav, Dr. Yogesh Yadav, Dr. Kapil Gupta, Dr. Jitendra Gupta, Dr. Abhishek Saini, Dr. Bhoopendra Patel, Dr. Amitabh Dube
Keywords
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