Neuroprotective Effect of Clerodendrum serratum in Amyloid β(25-35) Induced Amnesia Mice
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 8
Abstract
The content of the work is to determine the role of methanolic root extract of Clerodendrum serratum(CS) in amnesia induced mice by using β-amyloid peptide and compared with normal mice. The CS having anti-cancer, anti-helmenthic activity. But, the activity of root extract of CS as neuroprotective was not reported. Hence, the root extract of CS was tested for neuroprotective activity in neurodegenerative mice. The root extract were subjected to behavioral tests such as conditioned avoidance test, rectangular maze test, water maze test. Further, effect of extract on acetylcholinestarase, peroxidase, MDA levels and antioxidant activity is tested. From the results, it was observed that the root extract of CS exhibited statistically significant anti-amnesic and anti oxidant activity, when compared to normal mice. Therefore, the results conclusively demonstrate that, the chemical constituents of root extract responsible for neuroprotective activity, which might be due to oxidative stress. Keywords:Neuroprotective action, Clerodendrum serratum, amyloid β peptide, behavioral test and biochemical parameters.
Authors and Affiliations
Thirupathi G, Babu Rao B, Narsimha Reddy Y
Keywords
Related Articles
- EP ID EP378061
- DOI -
- Views 80
- Downloads 0
Evaluation of Hypoglycemic Effect of Crude Extracts and Different Fractions of Stem Bark of Acacia nilotica
Diabetes mellitus is a multifactorial disease which is characterized by hyperglycemia, lipoprotein abnormalities, raised basal metabolic rate, defect in reactive oxygen species scavenging enzymes and altered intermediary...
Phyto Pharmacology and Ethnomedical Approach of Terminaliachebula (Kadukkaai): A Review
Traditional medicine can take part a significant task in achieving the goal of ‘Health for All’ and is offered to assisting the integration of traditional medicine with Western medicine all over the world (WHO). As a par...
Modeling and In-Silico Evaluation of Some Flavonoids as Cyclooxygenases Inhibitors Phytochemicalsognes
In the inflammation process, the enzyme cyclooxygenase-2 expressed and its function is prostaglandins synthesis of from arachidonic acid so that to inhibit inflammation proses, COX-2 must be inhibited. In current researc...
Formulation and evaluation of fast dissolving tablets of simvastatin using novel co-processed superdisintegrants
The aim of the present investigation was to develop fast dissolving tablets of Simvastatin, an lipid-lowering drug used for the reduction of VLDL. Due to its low solubility and its short biological half-life of 3 hours,...
Study on Prevalence of Anaemia among School Children in a Rural Community Setup
Anaemia is one of the important public health problem, which affects the world’s population widely. Among all types of anaemia, iron deficiency anaemia is commonly seen in people of developing countries. The prevalence...