Neuroprotective effects of progesterone in acute brain trauma and its physiological mechanism
Journal Title: Journal of Acute Disease - Year 2018, Vol 7, Issue 1
Abstract
Traumatic brain injury (TBI) is the leading cause of death and neurological disability in young adults worldwide. This work aims to review the role of progesterone in traumatic brain injury and the usefulness as a possible treatment. We searched pubmed database (2000-2017) for articles containing "progesterone and brain traumatic injury". Basic science studies have advanced knowledge of the mechanisms of secondary brain injury, creating prospects for the medical and pharmacological management of TBI. Although several comparative studies evaluated both the efficacy and safety of several groups of drugs, in which, corticosteroids, tranexamic acid, 毬receptor antagonists, erythropoiesis-stimulating agents, reductase inhibitors include hydroxymethyl glutaryl-CoA inhibitors (statins), among others. Several studies even evaluated the role of progesterone in the treatment of TBI, which is providing growing evidence about its potential neuroprotective mechanisms during the acute phase of trauma. Despite recent advances in the field of management of TBI care in the emergency units, intensive care and the multiple trials for more than 20 years to find useful pharmacological treatments, most of these efforts failed in pre-clinical stages (II and III).
Authors and Affiliations
Luis Rafael Moscote-Salazar, Alexis Narvaez-Rojas, Amit Agrawal, Guru Dutta Satyarthee, Samer Hoz, Johana Maraby-Salgado, Andrei Joaquim
Keywords
Related Articles
- EP ID EP282508
- DOI 10.4103/2221-6189.228874
- Views 135
- Downloads 0
Survival following an impalement injury through the perineum in association with high voltage electrical burns: A case report
We reported a case of a 30-year-old man who reportedly sustained electrical burns and fell from a high voltage electric pole about 50 meter high onto a metal that caused impalement injury. In addition, he sustained full-...
Protective effects of Aristolochia longa and Aquilaria malaccensis against lead induced acute liver injury in rats
Objective: To investigate the protective effects of Aristolochia longa (A. longa) and Aquilaria malaccensis (A. malaccensis) on acute hepatotoxicity induced by lead in female albino rats. Methods: Twenty five (25) appare...
Efficiency of EBUS-TBNA for diagnosing benign and malignant lymphadenopathy
Objective: To determine whether endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can rapidly distinguish among lung cancer, tuberculosis and sarcodosis, and to explore its sensitivity and spec...
Surgical outcomes of acute acetabular transverse fracture using ilioinguinal and Stoppa approach
Objective: To compare surgical outcomes of acute acetabular transverse fracture using ilioinguinal and Stoppa approach. Methods: Twenty five patients who managed with ilioinguinal approach (group A) at a mean follow-up o...
Severe eclampsia and HELLP syndrome at 18 weeks of pregnancy in a patient with chronic hypertension
Preeclampsia is a pregnancy specific disease characterized by hypertension and proteinuria, by definition, developing after 20 weeks of pregnancy. Here we present an atypical case of severe preeclampsia complicated by ge...