Neuroprotective properties of statins.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 5
Abstract
Treatment with statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) reduces the risk of ischemic stroke among patients with increased risk of vascular disease. Recent experimental data point to neuroprotective properties of statins in acute cerebral ischemia. There is a proven link between bioavailability of nitric oxide and the activity of statins and ischemic stroke. Due to their ability to up-regulate nitric oxide synthase, statins have been considered in the therapy of a number of the central nervous system disorders, including cerebral ischemia, Alzheimer's disease, Parkinson's disease, tumors, and trauma. It has been claimed that they suppress inflammatory response and secondary injury after acute ischemia.
Authors and Affiliations
Karolina Stępień, Michał Tomaszewski, Stanisław Czuczwar
Keywords
Related Articles
- EP ID EP133821
- DOI -
- Views 103
- Downloads 0
Combined treatment with imipramine and metyrapone induces hippocampal and cortical brain-derived neurotrophic factor gene expression in rats.
The problem of drug-resistant depression indicates a strong need for alternative antidepressant therapies. Recently it was shown that joint administration of imipramine (IMI) and metyrapone (MET), an inhibitor of glucoco...
Role of β-adrenoceptors, cAMP phosphodiesterase and external Ca(2+) on polyamine-induced relaxation in isolated bovine tracheal strips.
Polyamines relax several smooth muscles and elicit cardiotonic effects in the rat heart via interactions with β-adrenoceptors. The aim of this work was to establish whether β(2)-adrenoceptors were involved in polyamine-r...
Sildenafil, a phosphodiesterase type 5 inhibitor, reduces antidepressant-like activity of paroxetine in the forced swim test in mice.
Background: Sildenafil, a selective phosphodiesterase 5 (PDE5) inhibitor, has recently been reported to influence the antidepressant activity of some antidepressant drugs. The present study was undertaken to investigate...
Effects of single and repeated in vitro exposure of three forms of parabens, methyl-, butyl- and propylparabens on the proliferation and estradiol secretion in MCF-7 and MCF-10A cells.
Background: Here, we analyzed the dose- (0.2, 2, 20, 200 nM or 2 μM) and time- (48, 96, 144 and 196 h) dependent activity of a single or repeated exposure of methyl-, butyl- and propylparaben on the proliferation of MCF-...
Potential hepato-protective effect of α-tocopherol or simvastatin in aged rats.
Background: The effect of α-tocopherol or simvastatin treatment on antioxidant defense in liver of old rats was investigated. Methods: Endogenous thiobarbituric acid reactive substances (TBARS) and total nitrite/nitrate...