Potential hepato-protective effect of α-tocopherol or simvastatin in aged rats.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 3
Abstract
Background: The effect of α-tocopherol or simvastatin treatment on antioxidant defense in liver of old rats was investigated. Methods: Endogenous thiobarbituric acid reactive substances (TBARS) and total nitrite/nitrate (NO(2)/NO(3)) levels as well as non-enzymatic glutathione (GSH) and enzymatic antioxidants [glutathione-S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) activities] were determined in the livers of young (3 months), aged (22 months), α-tocopherol- or simvastatin-treated aged rats. Serum lipid profile and liver function parameters were also assessed in these 4 groups. Results: Both α-tocopherol and simvastatin almost equally restored the age-induced changes in liver TBARS and CAT activity, serum aspartate aminotransferase (GOT), alanine aminotransferase (GPT) and alkaline phosphatase (ALP). α-Tocopherol, but not simvastatin, tended to restore GST and GPX activities in livers of aged rats. Simvastatin, on the other hand, counteracted age-induced increases in serum cholesterol, TG, LDL, total hepatic NO(2)/NO(3) level, and preserved a normal liver function during aging. Conclusion: Thus, either drug may be beneficial, in spite of a mechanistic difference in the antioxidant effect of both of them, in alleviating age-induced liver injury.
Authors and Affiliations
Mai Helmy
Keywords
Related Articles
- EP ID EP86909
- DOI -
- Views 94
- Downloads 0
Atherosclerotic risk among children taking antiepileptic drugs.
Epilepsy is a common chronic neurological disorder that requires long-term or sometimes lifetime therapy. Recent evidence indicates that prolonged use of antiepileptic drugs (AEDs) might modify some vascular risk factors...
Gestational manganese intoxication and anxiolytic-like effects of diazepam and the 5-HT1A receptor agonist 8-OH-DPAT in male Wistar rats.
In the present study, the effects of prenatal manganese (Mn) intoxication on the anxiolytic-like effects of diazepam and the 5-HT(1A) receptor agonist R-(+)-8-hydroxy-dipropylaminotetralin (8-OH-DPAT) were examined.Wista...
LC/MS/MS evaluation of cocaine and its metabolites in different brain areas, peripheral organs and plasma in cocaine self-administering rats.
We employed a cocaine intravenous self-administration model based on positive reinforcement of animals' instrumental reactions (i.e., lever pressing) rewarded by a dose of the drug. We also carried out simultaneous chara...
Impact of ABCB1 (MDR1) gene polymorphism and P-glycoprotein inhibitors on digoxin serum concentration in congestive heart failure patients.
Digoxin, a drug of narrow therapeutic index, is a substrate for common transmembrane transporter, P-glycoprotein, encoded by ABCB1 (MDR1) gene. It has been suggested that ABCB1 polymorphism, as well as co-administration...
Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.
Recently, it has been reported that metformin may attenuate inflammation and directly act on the central nervous system. Using the HPLC method, in Wistar rats, we assessed the changes in metformin concentrations in vario...