LC/MS/MS evaluation of cocaine and its metabolites in different brain areas, peripheral organs and plasma in cocaine self-administering rats.
Journal Title: Pharmacological Reports - Year 2012, Vol 64, Issue 6
Abstract
We employed a cocaine intravenous self-administration model based on positive reinforcement of animals' instrumental reactions (i.e., lever pressing) rewarded by a dose of the drug. We also carried out simultaneous characterization of the pharmacokinetics of cocaine and its metabolites in rats during withdrawal; in this part of the experiments, we investigated the cocaine (2 mg/kg, iv)-induced changes in the distribution, rate constant, clearance and t₁/₂ of the parent drug and its metabolites in different structures of the brain and in peripheral tissues.
Authors and Affiliations
Beata Bystrowska, Przemysław Adamczyk, Andrzej Moniczewski, Magdalena Zaniewska, Kjell Fuxe, Małgorzata Filip
Keywords
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