Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.

Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 5

Abstract

Recently, it has been reported that metformin may attenuate inflammation and directly act on the central nervous system. Using the HPLC method, in Wistar rats, we assessed the changes in metformin concentrations in various brain regions (pituitary gland, olfactory bulb, hypothalamus, cerebellum, hippocampus, striatum, frontal cortex), cerebrospinal fluid and plasma after single and chronic oral administration, in the model of systemic inflammation induced by lipopolysaccharide (ip). Regarding the influence of systemic inflammation on metformin distribution, the pituitary gland demonstrated the highest its level after single and chronic administration (28.8 ± 3.5 nmol/g and 24.9 ± 3.2 nmol/g, respectively). We concluded that orally-dosed metformin rapidly crosses the blood-brain barrier and differently accumulates in structures of the central nervous system.

Authors and Affiliations

Krzysztof Łabuzek, Dariusz Suchy, Bożena Gabryel, Anna Bielecka, Sebastian Liber, Bogusław Okopień

Keywords

Related Articles

Neonatal co-lesion by DSP-4 and 5,7-DHT produces adulthood behavioral sensitization to dopamine D(2) receptor agonists.

To assess the possible modulatory effects of noradrenergic and serotoninergic neurons on dopaminergic neuronal activity, the noradrenergic and serotoninergic neurotoxins DSP-4 N-(2-chlorethyl)-N-ethyl-2-bromobenzylamine...

Methamphetamine-induced neurotoxicity: the road to Parkinson's disease.

Studies have implicated methamphetamine exposure as a contributor to the development of Parkinson's disease. There is a significant degree of striatal dopamine depletion produced by methamphetamine, which makes the toxin...

Local pulmonary opioid network in patients with lung cancer: a putative modulator of respiratory function.

Recently, there has been growing interest in the opioid regulation of physiological respiratory function. However, evidence for a local opioid network that includes endogenous opioid peptides and their receptors is scarc...

Preclinical pharmacokinetics of radiolabelled hyaluronan.

Background: Hyaluronan (HYA) is a high molecular weight glucosaminoglycan with a great perspective for medical applications. Because HYA is widespread in the body, it is difficult to determine the fate of exogenously adm...

Effect of cyclooxygenase and nitric oxide synthase inhibitors on vincristine induced hyperalgesia in rats.

The purpose of this study was to investigate the effect of cyclooxygenase (COX) inhibitors and nitric oxide synthase (NOS) inhibitors on the development of vincristine (VIN)-induced hyperalgesia. Indomethacin (IND) and c...

Download PDF file
  • EP ID EP118912
  • DOI -
  • Views 88
  • Downloads 0

How To Cite

Krzysztof Łabuzek, Dariusz Suchy, Bożena Gabryel, Anna Bielecka, Sebastian Liber, Bogusław Okopień (2010). Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide.. Pharmacological Reports, 62(5), 956-965. https://europub.co.uk/articles/-A-118912