New opportunities of external antibacterial therapy
Journal Title: Український журнал дерматології, венерології, косметології - Year 2019, Vol 0, Issue 2
Abstract
Objective — to determine the principles of increasing the effectiveness of antibiotic therapy for pyococcal infections of the skin and soft tissues. Materials and methods. The study included 43 patients with severe and widespread dermatoses who were hospitalized in the dermatology department of the SE «Institute of Dermatology and Venereology of the NAMS of Ukraine». The identification of aerobic grampositive, aerobic gramnegative fermenting and nonfermentative bacteria isolated from different skin areas was performed using routine methods based on the morphological, cultural, and biochemical properties of the pathogens. Methods quality control for determining the sensitivity of microorganisms to antibiotics was performed using control strains of the American Typical Culture Collection (ATCC): S. aureus АТСС 25923, Е. соli АТСС 25922, P. аeruginosa АТСС 27853, E. faecalis АТСС 29212. Results and discussion. As a result of bacteriological examination, 59 strains of microorganisms were detected in patients, among which microorganisms of the genus Staphylococcus dominated, making the course of dermatoses more severe. In order to improve therapeutic efficacy and normalize the microbiocenosis, patients with severe chronic allergic dermatoses underwent external therapy, which included Mupirocin ointment. Due to the use of this scheme, in a period of exacerbation of the disease, 93.0 % of patients had regress of clinical signs of the pyococcal infection. Clinical remission was achieved in 27.9 % of patients, a significant improvement was noted in 53.5 %, improvement – in 11.6 %. Conclusions. The possibilities of using topical antibacterial agents, their mechanism of action, pharmacokinetics and the expediency of using mupirocin in the dermatological practice have been studied. This allows us to recommend mupirocin for the treatment of patients with chronic dermatoses who have received immunosuppressive therapy for a long time.
Authors and Affiliations
Yа. F. Kutasevych, S. K. Dzhoraeva, O. I. Oliinyk
Keywords
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- EP ID EP615101
- DOI 10.30978/UJDVK2019-2-63
- Views 81
- Downloads 0
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