NEW REAGENT FOR SPECTROPHOTOMETRIC DETERMINATION OF METFORMIN IN PURE FORMS AND IN PHARMACEUTICAL FORMULATIONS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 8
Abstract
An accurate, simple, fast and cheap spectrophotometric method has been developed for the determination of Metformin in pharmaceutical pure and dosage forms The method is based on the formation of violel complexe between metformin and chrome azurol S in phosphate buffer at pH=2.5. The resulting complex was measured at λmax=570 nm. The effect of variables such as reagent concentration, and metformin concentration investigated to optimize the procedure. Beer’s law was obeyed in concentration 3.31-57.96 μg/ml and the defection limits LOD and quantitation (LOQ) for proposed method are 0.781 and 2.660 μg/ml respectively, Recovary studies and statistical data proved the accuraty reproducbility of the proposed method. The common excipients did not inteffer in this analysis. Hence the methed is useful for routine estimtion of pure metformin and in pharmaceutical formulations.
Authors and Affiliations
Dr. Malek Okdeh
Keywords
Related Articles
- EP ID EP668114
- DOI -
- Views 130
- Downloads 0
TREND OF SPINAL CORD COMPRESSION SYNDROMES: AN ANALYSIS OF 529 CASES IN A TERTIARY HOSPITAL, IN NORTH-WESTERN NIGERIA
Background: Neurological disorders contributed to ninety two( 92) million Disability-Adjusted Life Years (DALYs) in 2005 and is projected to increase to 103 million in 2030. In view of this considerable morbidity associa...
EVALUATION OF CAPRYLINS BY THIN LAYER CHROMATOGRAPHY
This work aims to demonstrate the applicability of thin layer chromatography (TLC) coupled with the JustTLC 4.0.3 software for the evaluation of caprylins (mono-, di- and tricaprylin) in concentrated organic extracts obt...
A REVIEW ON MANAGEMENT OF OBESITY: PHARMACOLOGICAL VERSUS NON-PHARMACOLOGICAL APPROACH
When usual practice fails, people search for the new strategic management of obesity. Still the obesity is rarely cured, available treatment is only effective if they are continued in use. On stopping drug use, again the...
USE OF OPIACEA IN PATIENTS WITH CANCER AS PALLIATIVE CARE: REVIEW OF LITERATURE
According to the World Health Organization, it is unquestionable that cancer is a public health problem, therefore he importance of palliative care arises. It is an approach that improves the quality of life of patients...
EVALUATION OF THE EFFECTS OF Gutenbergia nigritana LEAVES EXTRACT ON CEREBELLUM OF ADULT MICE AND ITS IMPLICATION ON MANGANESE TOXICITY
Manganese is an important trace element in the biological system and its excessive exposure may lead to a neurological disorder known as manganism. Hence, checking the ameliorative effects of Gutenbergia nigritana leaves...