New secoiridoid ester of swertiamarin and secoxyloganic acid with hepatoprotective activity from Centaurium spicatum L.
Journal Title: Journal of Pharmacy & Pharmacognosy Research - Year 2015, Vol 3, Issue 3
Abstract
Context: Centaurium spicatum (L.) Fritsch (Gentianaceae) is an annual herb occurring in Southern Europe and Northern Africa where it is used in traditional medicine for treatment of numerous illness. Aims: To isolate compounds from C. spicatum having hepatoprotective activity. Methods: Structure elucidation of the new compound was established on the basis of 1D and 2D NMR analyses including 1H-, 13C- NMR, DEPT-135 NMR, HMQC, HMBC and H- H HOHAHA experiments in addition to FAB+ and HRFAB+ Mass spectrometry. In vivo transaminases inhibition activity was carried out. Results: A new ester of swertiamarin and secoxyloganic acid (1) was isolated from C. spicatum in addition to its known components secoiridoids swertiamarin (2) and secoxyloganic acid (3). All tested secoiridoids have transaminases inhibition activity with different values for each compound 1, 2, 3 (86, 83, 81%) for SGOT and (96, 93, 91%) for SGPT, respectively. Conclusions: The new ester compound from C. spicatum has hepatoprotective activity over than its components.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP196370
- DOI -
- Views 131
- Downloads 0
The profile of Brazilian agriculture as source of raw material to obtain organic cosmetics
The concept of organic products has expanded beyond food sector foods. Althougth it still causes resistance in some people, it has already captured a wide public, since the basic conditions that define organic products a...
Total phenols and flavonoids and antioxidant activity of Lampaya medicinalis F. Phil. leaf extracts
Context: Lampaya medicinalis F. Phil. (Verbenaceae) is a plant that grows in northern of Chile and it is used in ethnomedicine to treat bone pain, as an analgesic, in kidney ailments, disorders of the prostate, liver dis...
Validation of a technique by high-performance liquid chromatography for the determination of total isoflavones
Context: Isoflavones may act as selective regulators in the prevention of various diseases. The most important source of isoflavones is the soy, from which different phytotherapeutics are elaborated of use in Ecuadorian...
Traditional uses of medicinal plants at Seropédica, Rio de Janeiro
Context: This work had as outcome to deal with the part of the population of Seropédica, Rio de Janeiro those who use the public health system and use alternative medicinal plants for the treatment of illness. Aims: To...
Mangifera indica L. extract (Vimang) improves the aversive memory in spinocerebellar ataxia type 2 transgenic mice
Context: The spinocerebellar ataxia type 2 (SCA-2) is a progressive neurodegenerative disorder without specific therapy identified, and it is related to the loss of function in the cerebellum, mitochondrial dysfunction,...