NEW SPECTROPHOTOMETRIC DETERMINATION OFMETOCLOPRAMIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2015, Vol 3, Issue 12
Abstract
The new, selective and sensitive visible spectrophotometric method have been developed for the estimation of Metoclopramide in bulk and in pharmaceutical preparations. The amino group in Metoclopramide is diazotized with sodiumnitrite and hydrochloric acid at 00C temperature. After diazotization, the diazonium salt is coupled with resorcinol. The orange coloured chromogen formed in the method is stable for more than 24 hours. The orange colouredchromogen is used to determine the Metoclopramide spectrophotometrically.
Authors and Affiliations
Dr. A. J. PRATAPAREDDY| HOD Department of chemistry K.V.R. College, Nandigama.
Keywords
Related Articles
- EP ID EP1666
- DOI -
- Views 400
- Downloads 23
Possible Study of Drug-Drug Interactions between Lisinopril and Gliclazide in Experimental Animals
The most often problem in type II diabetic patients coexists with hypertension, the incidence of hypertension among diabetic patients is high. In this case, use a combination of medicine unavoidable (Polypharmacy). In su...
To Study and Evaluate the Various Aspects in Manufacturing Amorphous Spray Dried Dispersion.
Spray-dried dispersions have become an significant formulation technology for the pharmaceutical product development of poorly water-soluble compounds. Even though this technology is now widely used in the industry, espe...
Screening of solvent extracts of catharanthus roseus l. for isolation of anti-inflammatory compound
Catharanthus roseus (L.) which is an important medicinal plant of the family Apocynaceae is used to treat many of the fatal diseases. C. roseus also possess good antioxidant potential. Catharanthus roseus, is a potent me...
BIOCHEMICAL BASIS FOR USE OF CANNABINOIDS IN VARIOUS CLINICAL CONDITIONS
The broad range of potential therapeutic applications of cannabinoids reflects the wide distribution of cannabinoid receptors throughout the body. The possibility of distinct subtypes of cannabinoid receptors and the pr...
Anticancer activity of plant-derived proteins against human tumor cell lines
Cancer today represents a significant public health problem worldwide and the challenge is to produce cost-effective drugs. Recently, a surge of progress was achieved in the area of cytotoxic proteins. Eleven crude prote...