NEW SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF ATORVASTATIN CALCIUM AND ASPIRIN USING UREA AS HYDROTROPIC SOLUBILIZING AGENT
Journal Title: Hygeia:journal for drugs and medicines - Year 2017, Vol 9, Issue 2
Abstract
Plan: An analytical method for the simultaneous determination of Atorvastatin and Aspirin in capsule dosage form using 1.5M urea as hydrotropic solubilizing agent is described. Prologue: The method is simple, fast, & accurate and precludes the use of corrosive solvents and can be used for the routine analysis of commercial combinations of Atorvastatin and Aspirin. Methodology: The developed method used the simultaneous equation method (method-A)using 243 nm and 233 nm as absorbance maxima for ATR and ASP respectively and Q-absorbance ratio method (method-B), which is based on the measurement of absorptivity at iso-absorptive point 239 nm and 243 nm (absorption maximum of Atorvastatin). The calibration curves for both drugs were found to be linear in the concentration range of 10-50µg/ml. Outcome: The proposed method has been applied successfully for the simultaneous determination of Atorvastatin and Aspirin in capsule dosage form. The mean recovery of the drugs from the combination tablets was found to be 98.83 %for Atorvastatin and 97.77 % for Aspirin for method-A and 98.09 % and 98.06 % for method-B respectively. No significant interference was observed from urea and other excipients commonly used in the formulation.
Authors and Affiliations
SHYNI BERNARD, RANI SEBASTIAN, BABITHA M. C
Keywords
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- EP ID EP334110
- DOI 10.15254/H.J.D.Med.9.2018.169
- Views 21
- Downloads 0
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