Next Step in Chronic Kidney Disease Therapy
Journal Title: Нирки - Year 2016, Vol 2, Issue 16
Abstract
Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers are the basis of renoprotection therapy in chronic kidney disease. Parallel to decrease of glomerular filtration rate, there is an increase in the activity of the sympathetic nervous system, and the number of functioning nephrons reduces, which requires a change of treatment regimen. Reducing the risk of cardiovascular events on the background of increased hypertension probably dictates the need for a priority administration of sympatholytics, calcium channel blockers and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers withdrawal. ARAMONEL formula: ARAMONEL — AR(B)A(CEI)MO(xonidine)NE(bivolol)L(ercandipine) is changed to MNELD — M(oxonidine)NE(bivolol)L(ercandipine)D(iuretic) that is used by us in recent years. Combined use of torsemide and xipamide is allowed. Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers withdrawal requires evidence, which may be obtained in STOP-ACEi trial.
Authors and Affiliations
D. D. Ivanov
Keywords
Related Articles
- EP ID EP208349
- DOI -
- Views 86
- Downloads 0
Nifuratel Application in Therapy of Urinary Tract Infections
Increased multidrug resistance of extended-spectrum beta-lactamases (ESBLs) compromises the efficacy of treatment of urinary tract infections. The objective of this study is to determine the prevalence of ESBL-producing...
Antibiotic Resistance in Nephrological Practice
The problem of antibiotic resistance is a serious threat to the global public health and requires action by both the state and the public. The World Health Organization identified 15 most dangerous and prevalent superbug...
Heart rate variability in children with chronic pyelonephritis and I–III stages of chronic kidney disease
Background. Assessment of heart rate variability allows us to get an idea about the functional state of the autonomic nervous system and to identify changes in autonomic homeostasis in children. The purpose was to study...
New era of dialysis: expanded haemodialysis (HDx)
The article is addressed to practical physicians involved in renal replacement therapy, mainly haemodialysis (HD). The article presents a new method for haemodialysis — expanded haemodialysis, assesses its efficiency, an...
Precision diagnosis of lupus nephritis: opportunities and role of biomarkers
The most common complication in patients with systemic lupus erythematosus is lupus nephritis (LN), a condition that can lead to end-stage kidney disease. In recent years, many serum and urine biomarkers, genetic studies...