Nicardipine: Concise Review on Analytical Techniques
Journal Title: Archives of Nanomedicine: Open Access Journal - Year 2018, Vol 1, Issue 5
Abstract
Nicardipine (NCD) is the dihydropyridine class of calcium channel blockers. This study exits a concise review of analytical methods for the quantification of NCD in pharmaceutical preparations and biological fluids. NCD accessible single or in combination with added drugs in pharmaceutical matrices with many drugs like nifedipine, isradipine, veramipril, amlodipine and Aliskiren. They include numerous analytical techniques defined in this study for NCD were high-performance liquid chromatography (HPLC), UV-spectrophotometry, spectrofluorometry, electrochemical methods and liquid chromatography-mass spectroscopy (LCMS). The concise review explains the percentage utilization of the various approaches for analysis of NCD. Nicardipine is chemically identified as 1, 4-Dihydro-2, 6-dimethyl-4-(3-nitrophenyl)-3, 5-pyridinedicarboxylic acid methyl 2-[methyl-(phenylmethyl) amino]ethyl ester (Figure 1). The molecular weight of NCD is 479.52 [1]. The melting point of NCD in the range of 136-138 °C (277-280 °F) [2].It is a calcium channel antagonist class of dihydropyridine. It is now used for the treatment of angina pectoris and similarly used in the managing of hypertension [3]. Most CCBs, including amlodipine, felodipine, isradipine, nicardipine, and nifedipine, belong to the dihydropyridine class [4]. The dihydropyridine have little direct effect on cardiac tissue at typical therapeutic levels; yet, they can evoke reflex tachycardia [5].
Authors and Affiliations
Pritam Jain S, Vrushali Patil A, Ansari Shoaib Ahmed Ayaz Ahmed, Champalal Pawara T, Sanjay Surana J
Keywords
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- EP ID EP588993
- DOI 10.32474/ANOAJ.2019.01.000123
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