Bactericidal Biodegradable Films with Silver Nanoparticles for the Treatment of Burns
Journal Title: Archives of Nanomedicine: Open Access Journal - Year 2018, Vol 1, Issue 4
Abstract
Silver nanoparticles stabilized in a solution of sodium carboxymethylcellulose (Na-CMC) with a degree of substitution of 0.65-0.85 and degree of polymerization of 200-600 were synthesized. Physical, chemical properties, and antimicrobial activity of films prepared from sodium carboxymethylcellulose solutions containing silver nanoparticles were studied. The shapes, quantities, and sizes of the silver nanoparticles occurring in the sodium carboxymethylcellulose films were determined by atomic force microscopy and UV - spectroscopy. The shape, size, and quantity of silver nanoparticles determine their biological activity. At increase of the silver nanoparticle sizes of 5 up to 25 nm was found to enhance the microbicidal activitiy of the carboxymethylcellulose films. Design of medicinal biodegradable polymer films containing silver nanoparticles is one of promising ways in the development of new chemical and pharmaceutical products. Such films exhibit prolonged therapeutic and bactericidal activity [1]. The bactericidal properties of silver and its derivatives are well-known since ancient times. They are used in medicine. Recently, reports on the correlation between bactericidal properties of silver and its particle size have been published. In addition, it was shown that a decrease of the sizes of silver nanoparticles lead to a proportional increase in their antibacterial activity [2]. The synthesis of silver nanoparticles with a specified shape and size, stable and capable to keep their high chemical and biological activity for a long time is an important task [3]. Silver nanoparticles inhibit the activity of the enzyme-providing oxygen exchange in microorganisms, such as pathogenic bacteria, viruses, and fungi (about 700 species of pathogenic flora and fauna) [4]. The transition from the ionic Ag+ form to metallic nanoclusters makes possible to reduce silver toxicity to cells of higher organisms without suppression of the antimicrobial activity against pathogenic microflora. Silver nanoparticles, especially stabilized ones, have greater stability and prolonged action. Sodium carboxymethylcellulose (Na-CMC), water - soluble film forming biodegradable polymer is widely used in the production of oral pharmaceuticals and drugs for external use primarily to increase the viscosities of ointments, in the production of pastes as hydrogels, and in the production of drugs for parenteral use; it is of high interest as a stabilizer of silver nanoparticles. The aim of this study is to prepare stabilized silver nanoparticles in polymer films based on Na-CMC and to investigate their structures, physical and chemical properties, and bactericidal activity.
Authors and Affiliations
Yunusov Khaydar Ergashovich, Sarymsakov Abdushkur Abdukhalilovich, Rashidova Sayora Sharaphovna
Keywords
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- EP ID EP585467
- DOI 10.32474/ANOAJ.2018.01.000118
- Views 82
- Downloads 0
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