Nifuroxazide Erythema Pigmented Fixed: A Side Effect to Be Aware Off
Journal Title: Journal of Dermatology Research - Year 2022, Vol 3, Issue 1
Abstract
Erythema Pigmentum Fixata (EPF) is a delayed-type toxidermia. It manifests itself within 48 h after the re-introduction of a drug by the appearance of a recurrent rash, leaving a residual hyperpigmentation [1]. We report a first case of erythema pigmentosa fixed to Nifuroxazide. A 48-year-old man, chronic smoker, with a history of type 1 diabetes under insulin, having been amputated of the 4 limbs 5 years ago for ischemia of the limbs secondary to shepherd’s disease, suffering from a functional colopathy for which he often received symptomatic treatments includinf Nifuroxazide. The drug investigation revealed the ingestion of Nifuroxazide for a digestive episode after which he presented a rash composed of pruritic erythematous macules of the trunk and limbs with a 48-hour delay, evolving into post-inflammatory hyperpigmentation. The biopsy showed an interface dermatitis consisting of a predominantly lymphocytic infiltrate. The pharmaco-vigilance report accused Nifuroxazide. All the data allowed us to conclude to an erythema pigmentosa fixata. The patient did not present any more recurrence after eviction of the molecule.
Authors and Affiliations
Ryme Dassouli1*, Zakia Douhi1, Imane Kacimi1, Kenza Tahiri1, Hanane BayBay1, Sara Elloudi1, Fatima Zahra Mernissi1
Keywords
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- EP ID EP703202
- DOI https://doi.org/10.46889/JDR.2022.3107
- Views 43
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