Nigella sativa L. seeds melanin: A new hypoglycemic agent. Comparison with insulin in alloxan-diabetic rats
Journal Title: Scholars Academic Journal of Pharmacy - Year 2014, Vol 3, Issue 4
Abstract
The influence of Nigella sativa seeds melanin and insulin was compared in alloxan (185 mg/kg/i.p.) - diabetic rats regarding the blood glucose level, blood cells and other parameters and the body weights. Treatment of the animals with melanin 50 mg/kg i.p daily for three days or with insulin 5 IU/kg i.p for the same period induced significant decreases in the blood glucose level with a maximum of (49.5%) and (47.8%) on the 3rd day of treatment, respectively. Both treatments induced significant decreases in the number of leukocytes and lymphocytes (4.2-13.7%); compared with the diabetic control animals. Diabetes alone or melanin and insulin treatment of the diabetic animals suppressed the normal increase in body weight observed in the control non-diabetic animals. On broad basis, Nigella sativa melanin seemed to be a potential hypoglycemic agent. Keywords: Nigella sativa; melanin; alloxan; diabetic; rats
Authors and Affiliations
Al-Tayib O. A, El Tahir K. E, Idriss M. H, Eram K. E ,, Hassib A. M
Solanum xanthocarpum Chemical Constituents and Medicinal Properties: A Review
India with its knowledge of rich ancient traditional systems of medicine provides a strong base for the utilization of a large number of plants in general healthcare. Large number of herbal drugs existing in India, very...
Development and Validation of Dimenhydrinate Analysis Method in Tablet with Absorbance Method and Method of Area under Curve with Ultraviolet Spectrophotometry
Abstract: Methods of ultraviolet spectrophotometry have been developed and validated for the analysis of dimenhydrinate in tablets with absorbance methods and methods of areas under the curve. This method uses 0.1 M HCl...
Preparation and in vitro evaluation of cyclodextrin based piroxicam transdermal gel (release and permeation study)
Abstract:Piroxicam; a widely used non-steroidal anti-inflammatory drug(NSAID) , was prepared as a transdermal gel by mixing with a cyclodextrin in equal amounts and sodium carboxymethyl cellulose (NaCMC) as a matrix pol...
Isolation, antibacterial and antifungal evaluation of α-amyrenol from the root extract of Acacia ataxacantha DC
The root-bark of Acacia ataxacantha (Fabaceae) was investigated for medicinal potential. The Phytochemical screening indicated presence of flavonoids, glycosides, saponins, steroids/triterpenes, tannins and alkaloids. Th...
Hypothyroidism and Atherosclerosis: From Etiology to Pathophysiology
Atherosclerosis is a complex multifactorial disease, which develops in the arterial wall in response to various stimuli like hyperlipidemia, hyperhomocysteinemia, hypertension, smoking, metabolic disorders and results in...