Preparation and in vitro evaluation of cyclodextrin based piroxicam transdermal gel (release and permeation study)
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 3
Abstract
Abstract:Piroxicam; a widely used non-steroidal anti-inflammatory drug(NSAID) , was prepared as a transdermal gel by mixing with a cyclodextrin in equal amounts and sodium carboxymethyl cellulose (NaCMC) as a matrix polymer in 3 and 6% concentrations. Piroxicam was examined for its melting point and characterized by its fourier transform infrared (FTIR) spectra and differential scanning calorimetry (DSC). The prepared formulas were tested in terms of their release and diffusion behavior and compared with a marketed piroxicam gel. The results of the release and diffusion studies were subjected into different mathematical models to elucidate the pattern and mechanism of their release and diffusion.It was concluded that (F1) which contain 0.15 g of piroxicam and cyclodextrin in a matrix consist of 3% NaCMC represent the best one in terms of release and diffusion during the study period where 95% of piroxicam released during 3 hours and 78% of the drug was diffused through cellophane membrane during 4 hours. Keywords:non-steroidal anti-inflammatory drug, sodium carboxymethyl cellulose, differential scanning calorimetry.
Authors and Affiliations
QasimAllawi Bader
Keywords
Related Articles
- EP ID EP378108
- DOI -
- Views 84
- Downloads 0
A Study of Prognostic Indicators in Patients of Severe Falciparum Malaria on Treatment with Artesunate And Quinine
Severe falciparum malaria is a common and fatal malarial illness. The recommended regimen for severe falciparum malaria includes either artesunate or quinine based treatment. 100 patients of severe falciparum malaria we...
Alternative Treatment of Methicillin Resistant Staphylococcus aureus Infections: An Update
Abstract: Vancomycin has been a predominant treatment for methicillin-resistant Staphylococcus aureus (MRSA) infections for decades. Due to the resurgence of some resistant and intermediate strains to vancomycin, it is n...
Synthesis and Antibacterial Activity of 4-Methoxy Phenyl Propenone Chalcones
Abstract: Chalcones belongs to a class of naturally occurring compounds called flavonoids which are found in plants and they are known to possess variety of biological activities. They are very useful and good lead compo...
Prescribing Patterns of Antihypertensive Drugs in A Tertiary Care Hospital
The choice of drug for the treatment of hypertension changes at short intervals. Drug utilization studies conducted at regular intervals help to guide the physician in prescribing drugs rationally. The present study was...
Detection and estimation of well-known free radical scavengersrutin, quercetin andgallic acid in market herbal anti-inflammatoryand anti-arthritis formulations by HPTLC Methods
The prime aim of the swot up is to observe the flavonoids and phenolic acids in three commercial herbal anti-arthritis formulations. HPTLC method was adopted to confirm the presence of these common secondary metabolites...