No association of three GRIN2B polymorphisms with lithium response in bipolar patients.
Journal Title: Pharmacological Reports - Year 2009, Vol 61, Issue 3
Abstract
We investigated three polymorphisms in the NMDA receptor 2B subunit gene (GRIN2B) as a candidate gene for lithium response involved in glutamatergic neurotransmission. One hundred five bipolar patients treated with lithium for at least 5 years were analyzed. The lithium response was assessed as excellent - no affective episodes during lithium treatment; partial - 50% reduction in the episode index; or no response - less than 50% reduction, no change or worsening in the episode index. Genotypes for the -200G/T, 366C/G and rs890G/T GRIN2B polymorphisms were established using the PCR-RFLP method. Genotype distributions were in Hardy-Weinberg equilibrium for all three polymorphisms. No association was found between the three polymorphisms studied and the treatment response to lithium. The authors conclude that polymorphisms of the GRIN2B gene did not show an association with the treatment response to lithium in bipolar patients.
Authors and Affiliations
Aleksandra Szczepankiewicz, Maria Skibińska, Joanna Hauser, Janusz Rybakowski
Keywords
Related Articles
- EP ID EP113181
- DOI -
- Views 81
- Downloads 0
Effects of standard treatment on the dynamics of matrix metalloproteinases gene expression in patients with acute coronary syndromes.
Inflammation plays a critical role in the pathology of acute coronary syndrome (ACS). Matrix metalloproteinases (MMP) - proteolytic enzymes participating in plaque destabilization - are the crucial effectors of proinflam...
Anti-inflammatory plasma cytokines in children and adolescents with migraine headaches.
Studies have shown fluctuations of cytokine levels in patients with migraine headaches; however, further studies are needed to verify these results. Our previous studies suggest increased levels of pro-inflammatory cytok...
Corticotropin-releasing factor microinjection into the central nucleus of the amygdala alters REM sleep.
Psychological stressors have a prominent effect on rapid eye movement sleep (REMS) in humans and animals. We hypothesized that the stress-related neurochemical corticotropin-releasing factor (CRF), acting in the amygdala...
Long-term inhibition of intestinal lipase by orlistat improves release of gut hormones increasing satiety in obese women.
Background: Reduced postprandial secretion of peptide YY (PYY), glucagon-like peptide-1 (GLP-1), cholecystokinin, and increased hunger was reported after a single dose of orlistat, an inhibitor of intestinal lipase. As y...
Different effects of perindopril and enalapril on monocyte cytokine release in coronary artery disease patients with normal blood pressure.
Favorable effects of angiotensin-converting enzyme (ACE) inhibitor treatment on the incidence of cardiovascular and cerebrovascular mortality and morbidity are not limited to patients with elevated blood pressure. As sug...