Non-Albicans Candida among Symptomatic Vulvovaginal Candidiasis Women in Onitsha, Nigeria
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 6
Abstract
Background: Non-albicans Candida (NAC) species have emerged as important causes of Vulvovaginal candidiasis (VVC) among women of reproductive age. The aim of this study was to establish an association between NAC and symptomatic VVC among female patients in Onitsha, Nigeria. Method: High vaginal specimens from a total of 876 women were evaluated mycologically by standard methods, involving microscopic examination and culture using sabouraud dextrose agar (SDA) and Brilliance Candida agar. Susceptibility of isolates to fluconazole and itraconazole were tested using agar dilution method. Result: Of the 876 samples; yeasts were isolated in 484 (55.3%). The overall occurrence of Non-albicans Candida species was 45%: Candida glabrata (18.2%), Candida krusei (11.6%), Candida tropicalis (4.1%) and Candida dubliniensis (4.1%) and other non-albicans (7%). Among the subjective symptoms presented, vulval pruritus was the commonest (81%), followed by vaginal discharge (70%). High resistance to Itraconazole was observed among non-albicans increasingly involved in VVC. C. tropicalis, C. dubliniensis, C. krusei and C. glabrata showed 100%, 50%, 40% and 25% resistance to Itraconazole respectively. Susceptibility to Fluconazole was 100%. Conclusion: The epidemiological study revealed that NAC is associated with symptomatic VVC. Vulvovaginal Candidiasis is of serious public health concern which affects millions of women annually. Non-albicans Candida has gradually been characterized as the cause of VVC thus posing an emerging threat.
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Ejike Chinwe E
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